{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:07:06Z","timestamp":1788217626453,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010136920"],"award-info":[{"award-number":["MOP\u2010136920"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Fonds de Recherche du Qu\u00e9bec - Nature et Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated the association between the Fas\u2010670A\/G and the Fas ligand FasL IVS2nt 124 A\/G polymorphisms and the risk of pre\u2010eclampsia and its complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A case\u2010controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University Hospitals in most areas of Tunisia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>We recruited 300 pregnant women who developed pre\u2010eclampsia and 300 age\u2010matched healthy pregnant women from the same hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genotyping of Fas\u2010670A\/G and the FasL IVS2nt 124A\/G gene polymorphisms were conducted using polymerase chain reaction\u2010restriction fragment length polymorphism among our cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Fisher's exact test was used to compare the statistical differences between groups for categorical variables and Student <jats:italic>t<\/jats:italic> tests were used for continuous variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of the Fas\u2010670G gene variant was significantly increased in women with pre\u2010eclampsia (42%) compared with control women (30%; <jats:italic>P<\/jats:italic> &lt; 0.001). Also, a statistically significant difference was obtained in the distribution of the FasL IVS2nt 124G gene variant when comparing women with pre\u2010eclampsia (43%) with controls (30%; <jats:italic>P<\/jats:italic> &lt; 0.001). Interestingly, we found that the carriage of Fas\u2010670G was associated with increased liver enzymes, suggesting an increased prevalence of the haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, a pre\u2010eclampsia complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Fas\u2010670G and FasL IVS2nt 124G polymorphisms are associated with a higher risk of pre\u2010eclampsia and its complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Polymorphisms in the Fas and FasL genes are associated with increased risk of pre\u2010eclampsia and HELLP syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15412","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T14:19:38Z","timestamp":1533133178000},"page":"1758-1764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["FAS A\u2010670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre\u2010eclampsia and may contribute to HELLP syndrome: a case\u2010controlled study"],"prefix":"10.1111","volume":"125","author":[{"given":"N","family":"Raguema","sequence":"first","affiliation":[{"name":"Laboratory of Human Genome and Multifactorial Diseases (LR12ES07) Faculty of Pharmacy of Monastir University of Monastir Monastir Tunisia"},{"name":"Faculty of Sciences of Bizerte University of Carthage Jarzouna\u2010 Bizerte Tunisia"},{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) Montr\u00e9al QC Canada"},{"name":"School of Kinesiology and Physical Activity Sciences Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Zitouni","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genome and Multifactorial Diseases (LR12ES07) Faculty of Pharmacy of Monastir University of Monastir Monastir Tunisia"},{"name":"Faculty of Sciences of Bizerte University of Carthage Jarzouna\u2010 Bizerte Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ben Ali Gannoun","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genome and Multifactorial Diseases (LR12ES07) Faculty of Pharmacy of Monastir University of Monastir Monastir Tunisia"},{"name":"Faculty of Sciences of Bizerte University of Carthage Jarzouna\u2010 Bizerte Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Benletaifa","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genome and Multifactorial Diseases (LR12ES07) Faculty of Pharmacy of Monastir University of Monastir Monastir Tunisia"},{"name":"Faculty of Medicine of Sousse University of Sousse Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WY","family":"Almawi","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genome and Multifactorial Diseases (LR12ES07) Faculty of Pharmacy of Monastir University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) Montr\u00e9al QC Canada"},{"name":"School of Kinesiology and Physical Activity Sciences Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists: Task Force on Hypertension in Pregnancy","volume":"122","author":"American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","year":"2013","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-014-2659-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087621"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1434.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186909"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.6.2188"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191220570"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000148547.70187.89"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.2.213"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.1.39.44"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400964"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/6.10.1567"},{"key":"e_1_2_6_14_1","first-page":"1183","article-title":"A functional polymorphism in fas (CD95\/APO\u20101) gene promoter associated with systemic lupus erythematosus","volume":"29","author":"Kanemitsu S","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(97)00081-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12327"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.132"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.10.026"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah151"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2013.10.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13062"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJCIIS.IJCIIS_33_17"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000195824.51919.81"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1408-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9808426"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah129"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200112000-00019"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.01.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320289"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.202406"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.011"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.15412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T21:02:18Z","timestamp":1694811738000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,3]]},"references-count":31,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/1471-0528.15412"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15412","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,3]]},"assertion":[{"value":"2018-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}