{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:06:46Z","timestamp":1780553206214,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long\u2010term follow\u2010up on the growth of these children is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically review the literature on post\u2010neonatal height and weight among children conceived following in\u00a0vitro fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) or intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>) treatment, compared with that of children born after spontaneous conception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Cohort or case\u2013control studies with an exposed group of singletons conceived following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> along with a control group of spontaneously conceived singletons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Studies were reviewed by at least two authors. Meta\u2010analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle\u2013Ottawa Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Twenty studies were included, with 13 of these eligible for meta\u2010analyses. The meta\u2010analyses compared 3972 children born after <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> with 11\u00a0012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) in weight of \u2212160\u00a0g; 95% confidence interval (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) \u2212360, 3]. When stratifying by age of child at follow\u2010up, we found a significant lower weight in children aged 0\u20134\u00a0years conceived following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> treatment (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u2212180\u00a0g; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u2212320, \u22124), but this was no longer significant in children from 5\u00a0years of age (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u2212160\u00a0g; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u2212580, 260). The pooled analysis revealed no statistically significant difference in childhood height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In\u00a0vitro fertilisation\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> was not associated with long\u2010term weight and height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Children born following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> do not have impaired long\u2010term weight or height compared with spontaneously conceived children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15456","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T04:44:39Z","timestamp":1535690679000},"page":"158-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"B","family":"Bay","sequence":"first","affiliation":[{"name":"The Fertility Clinic Regional Hospital Horsens Horsens Denmark"},{"name":"Department of Obstetrics and Gynaecology Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lyngs\u00f8","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section\u00a0for Epidemiology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Hohw\u00fc","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Public Health and Epidemiology Group Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"US","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Herlev and Gentofte Hospital Herlev Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000114989.84822.51"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62116-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den309"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.04.049"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg445"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.12.037"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew106"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.02.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2465"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1542\/peds.97.5.688","article-title":"Growth and physical outcome of children conceived by in\u00a0vitro fertilization","volume":"97","author":"Saunders K","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0950115"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91224-A"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7181.427"},{"key":"e_1_2_6_16_1","unstructured":"GAWells BS O'ConnellD PetersonJ WelchV LososM TugwellP.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses.2005. 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