{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:58:17Z","timestamp":1784350697542,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Background<\/jats:title>Fallopian tube occlusion is a common cause of infertility, but the effect of unilateral tubal block (UTB<\/jats:styled-content>) on pregnancy rates (PR<\/jats:styled-content>) after controlled ovarian hyperstimulation and intrauterine insemination (COH<\/jats:styled-content>\u2010IUI<\/jats:styled-content>) remains controversial.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate PR<\/jats:styled-content> after COH<\/jats:styled-content>\u2010IUI<\/jats:styled-content> among infertile women with proximal and distal UTB<\/jats:styled-content> diagnosed by hysterosalpingogram (HSG<\/jats:styled-content>), compared against women with bilateral patent tubes experiencing unexplained infertility.<\/jats:p><\/jats:sec>Search strategy<\/jats:title>We searched EMBASE<\/jats:styled-content>, MEDLINE<\/jats:styled-content>, Google Scholar, Cochrane Library, and PUBMED<\/jats:styled-content> from inception to 14 January 2018.<\/jats:p><\/jats:sec>Selection criteria<\/jats:title>Studies that report PR<\/jats:styled-content>\/cycle or cumulative PR<\/jats:styled-content> among women with UTB<\/jats:styled-content> and controls were included.<\/jats:p><\/jats:sec>Data collection and analysis<\/jats:title>Two authors independently selected and extracted study characteristics and data. Methodological quality was assessed using the Preferred Reporting Items for Systematic Reviews and Meta\u2010analysis (PRISMA<\/jats:styled-content>) guidelines.<\/jats:p><\/jats:sec>Main results<\/jats:title>Among 2965 patients and 5749 IUI<\/jats:styled-content> cycles across ten studies, no significant difference in PR<\/jats:styled-content>\/cycle (odds ratio, OR<\/jats:styled-content> = 0.88; 95% confidence interval, 95% CI<\/jats:styled-content> = 0.69\u20131.12) and cumulative PR<\/jats:styled-content> (OR<\/jats:styled-content> = 0.80, 95% CI<\/jats:styled-content> = 0.62\u20131.04) was observed. Patients with proximal UTB<\/jats:styled-content> demonstrated similar PR<\/jats:styled-content>\/cycle (OR<\/jats:styled-content> = 1.06, 95% CI<\/jats:styled-content> = 0.68\u20131.66) and cumulative PR<\/jats:styled-content> (OR<\/jats:styled-content> = 1.10, 95% CI<\/jats:styled-content> = 0.75\u20131.62), compared with controls, whereas patients with distal UTB<\/jats:styled-content> had significantly lower cumulative PR<\/jats:styled-content> (OR<\/jats:styled-content> = 0.49, 95% CI<\/jats:styled-content> = 0.25\u20130.97, P<\/jats:italic> = 0.04). Patients with proximal block also demonstrated significantly improved cumulative PR<\/jats:styled-content>, compared with patients with distal block (OR<\/jats:styled-content>=2.41, 95% CI<\/jats:styled-content> = 1.37\u20134.25, P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Infertile patients with proximal UTB<\/jats:styled-content> diagnosed by HSG<\/jats:styled-content> can expect similar pregnancy rates after COH<\/jats:styled-content>\u2010IUI<\/jats:styled-content>, compared with those with bilateral tubal patency and unexplained infertility, whereas patients with distal UTB<\/jats:styled-content> have lower odds of pregnancy. These differences may reflect inherent diagnostic limitations of HSG<\/jats:styled-content> or differences in underlying pathologies.<\/jats:p><\/jats:sec>Tweetable abstract<\/jats:title>Meta\u2010analysis evaluates pregnancy outcomes after COH<\/jats:styled-content>\u2010IUI<\/jats:styled-content> in women with unilateral tubal block diagnosed by HSG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15457","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T16:38:33Z","timestamp":1535733513000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of unilateral tubal block diagnosed by hysterosalpingogram on clinical pregnancy rate in intrauterine insemination cycles: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"J","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tannus","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology McGill University Health Care Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Taskin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AY","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Bedaiwy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.09.035"},{"key":"e_1_2_6_3_1","first-page":"730513","article-title":"Clinical effectiveness of modified laparoscopic fimbrioplasty for the treatment of minimal endometriosis and unexplained infertility","volume":"2015","author":"Franjoine SE","year":"2015","journal-title":"Minim Invasive Surg"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57781-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81363-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.187"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2012.01.037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2012.39.2.68"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_6_10_1","unstructured":"WellsGA SheaB O\u2019CD PetersonJ WelchV LososM.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of non\u2010randomised studies in meta\u2010analyses. Proceedings on the Third Symposium on Systematic Reviews Beyond the Basics Improving Quality and Impact. 2000."},{"key":"e_1_2_6_11_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.05.018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v0i2.39"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.2016.0289"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2013.853030"},{"issue":"59","key":"e_1_2_6_17_1","first-page":"1","article-title":"Efficacy of ovarian stimulation and intrauterine insemination in women with unilateral tubal occlusion diagnosed by hysterosalpingography","author":"Yukiyo S","year":"2012","journal-title":"Jikeikai Med J"},{"key":"e_1_2_6_18_1","first-page":"15","article-title":"Controlled ovarian hyperstimulation and intrauterine insemination cycles in patients with unilateral tubal blockage diagnosed by hysterosalpingography","volume":"9","author":"Ebrahimi M","year":"2011","journal-title":"Iran J Reprod Med"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjod.88786"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.08.003"},{"key":"e_1_2_6_21_1","unstructured":"National Institute for Health and Clinical Excellence.Fertility: assessment and treatment for people with fertility problems 2013. [https:\/\/www.nice.org.uk\/guidance\/cg156\/evidence\/full-guideline-pdf-188539453]. Accessed 25 March 2018."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1027"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00415-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu024"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq056"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.63117"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2305-0500(13)60056-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.12.031"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1375183"}],"container-title":["BJOG: An International Journal of Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.15457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.15457","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:56:54Z","timestamp":1694714214000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,24]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/1471-0528.15457"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15457","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,24]]},"assertion":[{"value":"2018-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}