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Linear mixed modelling was applied to compare the effect of <jats:styled-content style=\"fixed-case\">MBSR<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">CAU<\/jats:styled-content> over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3 and 12\u00a0months, there were statistically significant improvements in the <jats:styled-content style=\"fixed-case\">MENQOL<\/jats:styled-content> for the <jats:styled-content style=\"fixed-case\">MBSR<\/jats:styled-content> group compared with the <jats:styled-content style=\"fixed-case\">CAU<\/jats:styled-content> group (both <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). At 3\u00a0months, the mean <jats:styled-content style=\"fixed-case\">MENQOL<\/jats:styled-content> scores were 3.5 (95% confidence interval, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.0\u20133.9) and 3.8 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.3\u20134.2) for the <jats:styled-content style=\"fixed-case\">MBSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAU<\/jats:styled-content> groups, respectively; at 12\u00a0months, the corresponding values were 3.6 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.1\u20134.0) and 3.9 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.5\u20134.4). No significant differences were found between the <jats:styled-content style=\"fixed-case\">MBSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAU<\/jats:styled-content> groups in the other scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mindfulness\u2010based stress reduction was effective at improving quality of life in the short\u2010 and long\u2010term for patients with menopausal symptoms after <jats:styled-content style=\"fixed-case\">RRSO<\/jats:styled-content>; however, it was not associated with an improvement in sexual functioning or distress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Mindfulness improves menopause\u2010related quality of life in women after risk\u2010reducing 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