{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:06:59Z","timestamp":1773284819512,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the tocolytic action of nifedipine combined with sildenafil citrate (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) and if the combination is superior to nifedipine alone in inhibiting threatened preterm labour (<jats:styled-content style=\"fixed-case\">PTL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective randomised study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An Egyptian university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with threatened <jats:styled-content style=\"fixed-case\">PTL<\/jats:styled-content> who received either nifedipine with <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> or nifedipine alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomly allocated to receive either (1) nifedipine 20\u00a0mg orally (stat dose), followed by 10\u00a0mg orally every 6\u20138\u00a0hours at the same time as vaginal administration of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> (25\u00a0mg at 8\u2010hourly intervals) or (2) nifedipine alone. Medications were continued for 48\u201372\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The percentage of women who remained undelivered during hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2015 to November 2016, 239 women were randomised. The baseline characteristics of participants were similar. Nifedipine combined with <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> was associated with more women remaining undelivered (81.8 versus 68.6%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018) during hospitalisation. Regarding secondary outcomes, the addition of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> was also associated with fewer deliveries within 7\u00a0days of admission (9.1 versus 20.3%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.014), prolonged latency (29 versus 7\u00a0days; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002), fewer admissions to neonatal intensive care units (31.4 versus 44.1%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.043), fewer very preterm deliveries (from 28 to &lt;32\u00a0weeks, 20.7 versus 38.1%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.043), and increased neonatal birthweight (1900 versus 1500\u00a0g; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vaginal <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> combined with nifedipine is an effective option for tocolytic therapy during threatened PTL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Vaginal <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> enhances the tocolytic effect of nifedipine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15503","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T09:03:56Z","timestamp":1539421436000},"page":"729-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Retracted:<\/i> Nifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial"],"prefix":"10.1111","volume":"126","author":[{"given":"MA","family":"Maher","sequence":"first","affiliation":[{"name":"Faculty of Medicine Menoufia University Shebin\u2010Elkom Egypt"},{"name":"Al\u2010Hayat National Hospital Khamis\u2010Mushait Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TM","family":"Sayyed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University Shebin\u2010Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SW","family":"El\u2010khadry","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics National Liver Institute Menoufia University Shebin\u2010Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00275-V"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp131"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.073"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0004-8666.2003.00074.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.11.038"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703657"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90500-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825af2f0"},{"key":"e_1_2_6_11_1","unstructured":"National Institute for Health and Clinical Excellence.Preterm labour and birth. 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