{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:33:19Z","timestamp":1783431199209,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the risk of stillbirth in low\u2010risk <jats:italic>in vitro<\/jats:italic> fertilisation (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Register\u2010based national cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Denmark 2003\u20132013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Cohort of 425 732 singleton pregnancies including 10 235 conceived following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>), 4521 conceived following intrauterine insemination (<jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content>), and 410 976 spontaneously conceived.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information on pregnancy, obstetrical risk factors, stillbirth, and fertility treatment was obtained from the Danish national health registers for all pregnancies after gestational week 21<jats:sup>+6<\/jats:sup>. We estimated the overall and gestational age\u2010specific risk of stillbirth in low\u2010risk term pregnancies following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ICSI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content>. Further, we estimated the association between stillbirth and <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> respectively as well as fresh or frozen\u2010thawed embryo transfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Risk of stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of stillbirths in spontaneously conceived and <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> low\u2010risk term pregnancies was 525 (0.1%) and 35 (0.3%), respectively. In multivariate analysis, the risk of stillbirth in pregnancies following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> was increased (odds ratio 2.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20133.1). The risk of stillbirth was correspondingly increased in time\u2010to\u2010event analyses taking risk time for each fetus into account from gestational week 37 and onwards (hazard ratio 2.4, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.6\u20133.6). In sub\u2010analyses, the risk of stillbirth was increased for pregnancies following <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> (odds ratio 2.2, 95% CI 1.2\u20133.1), but not <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">odds ratio<\/jats:styled-content> 1.7, 95% CI 0.9\u20133.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a systematically increased risk of stillbirth in low\u2010risk term pregnancies following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>. Whether the risk was related to the treatment or to underlying subfertility is uncertain. The results may indicate a need for obstetrical surveillance for these pregnancies when reaching term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Increased risk of stillbirth in low\u2010risk term pregnancies following fresh cycle IVF\/ICSI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15509","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T17:04:17Z","timestamp":1540055057000},"page":"253-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Risk of stillbirth in low\u2010risk singleton term pregnancies following fertility treatment: a national cohort study"],"prefix":"10.1111","volume":"126","author":[{"given":"B","family":"Bay","sequence":"first","affiliation":[{"name":"The Fertility Clinic Department of Gynaecology and Obstetrics Regional Hospital Horsens Horsens Denmark"},{"name":"Department of Gynaecology and Obstetrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Boie","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Regional Hospital Randers Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"US","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Herlev and Gentofte Hospital Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000114989.84822.51"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq023"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080398"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70514-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu031"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.07.1092"},{"key":"e_1_2_7_10_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Labour induction after IVF.2013(https:\/\/www.rcog.org.uk\/en\/guidelines-research-services\/guidelines\/kleihauer-test-in-antepartum-haemorrhage---query-bank1\/). Accessed 30 April 2018."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"e_1_2_7_12_1","first-page":"357","article-title":"The Danish in vitro fertilisation (IVF) register","volume":"46","author":"Andersen AN","year":"1999","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_2_7_14_1","volume-title":"Stata Statistical Software: Release 12","author":"Statacorp","year":"2011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60131-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92154-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00159-O"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b76bd1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei424"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f108"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61041-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.02.038"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.15509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.15509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:56:02Z","timestamp":1694714162000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,16]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/1471-0528.15509"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15509","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,16]]},"assertion":[{"value":"2018-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}