{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:55:02Z","timestamp":1791230102497,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the obstetric outcome of women carriers of the oxidative phosphorylation (<jats:styled-content style=\"fixed-case\">OXPHOS<\/jats:styled-content>) disorder mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study in a single tertiary centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A review of the obstetric history of women referred for prenatal screening of a mitochondrial disorder was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women were divided into three groups: (1) women carrying mitochondrial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>) mutations; (2) healthy women with a family history of mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">OXPHOS<\/jats:styled-content> disorder; and (3) healthy women carrying heterozygote nuclear <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Obstetric history and pregnancy complications were evaluated separately in the three groups and compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures pregnancy complications.Results<\/jats:title><jats:p>Seventy\u2010five women were included with 287 cumulative pregnancies. Groups 1 and 3 had a significantly greater proportion of terminations of pregnancy (20 and 13% versus 0.8%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and a lower percentage of live births (52 and 72% versus 87%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), compared with controls. Apart from this, the rate of obstetric complications in group 3 did not differ from the controls. The obstetric history of women in group 1 was marked by higher rates of early miscarriages (26 versus 11%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), gestational diabetes (14 versus 3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, 10 versus 1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), and postpartum haemorrhage than were reported for controls (12 versus 2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women who are heteroplasmic for <jats:styled-content style=\"fixed-case\">OXPHOS<\/jats:styled-content> mutations have a higher incidence of pregnancy losses, gestational diabetes, <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, and post postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Women heteroplasmic for mitochondrial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutations have a higher incidence of obstetric complications, compared with the control group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15515","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T08:23:10Z","timestamp":1542788590000},"page":"1372-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Increased incidence of obstetric complications in women carrying mitochondrial <scp>DNA<\/scp> mutations: a retrospective cohort study in a single tertiary centre"],"prefix":"10.1111","volume":"126","author":[{"given":"M","family":"Kuleva","sequence":"first","affiliation":[{"name":"Department of Obstetrics Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ben 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