{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:34:55Z","timestamp":1793298895975,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Richard and Jack Wiseman Trust"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,4]]},"abstract":"\n Background<\/jats:title>\n Single intrauterine fetal death affects approximately 6% of twin pregnancies and can have serious sequelae for the surviving co\u2010twin.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n Determine the prognosis of the surviving co\u2010twin following spontaneous single intrauterine fetal death to aid counselling patients and highlight future research areas.<\/jats:p>\n <\/jats:sec>\n \n Search strategy<\/jats:title>\n Medline, Embase, Web of Science, and Cochrane Library, from 1980 to June 2017.<\/jats:p>\n <\/jats:sec>\n \n Selection criteria<\/jats:title>\n Studies of five or more cases of spontaneous single intrauterine fetal death after 14\u00a0weeks gestation, in diamniotic twin pregnancies.<\/jats:p>\n <\/jats:sec>\n \n Data collection and analysis<\/jats:title>\n Summary event rates were calculated and stratified by chorionicity. Monochorionic and dichorionic twins, and sub\u2010groups, were compared by odds ratios.<\/jats:p>\n <\/jats:sec>\n \n Main results<\/jats:title>\n \n In monochorionic twins, when single intrauterine fetal death occurred at less than 28\u00a0weeks\u2019 gestation, this significantly increased the rate of co\u2010twin intrauterine fetal death [\n odds ratio (OR)<\/jats:styled-content>\n 2.31, 95%\n confidence interval (CI)<\/jats:styled-content>\n 1.02\u20135.25,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00.0%, 12 studies, 184 pregnancies] and neonatal death (\n OR<\/jats:styled-content>\n 2.84, 95%\n CI<\/jats:styled-content>\n 1.18\u20136.77,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00.0%, 10 studies, 117 pregnancies) compared with when the single intrauterine fetal death occurred at more than 28\u00a0weeks\u2019 gestation. Neonatal death in monochorionic twins was significantly higher if the pregnancy was complicated by fetal growth restriction (\n OR<\/jats:styled-content>\n 4.83, 95%\n CI<\/jats:styled-content>\n 1.14\u201320.47,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00.0%, six studies, 60 pregnancies) or preterm birth (\n OR<\/jats:styled-content>\n 4.95, 95%\n CI<\/jats:styled-content>\n 1.71\u201314.30,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00.0%, 11 studies, 124 pregnancies). Abnormal antenatal brain imaging was reported in 20.0% (95%\n CI<\/jats:styled-content>\n 12.8\u201331.1,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a021.9%, six studies, 116 pregnancies) of surviving monochorionic co\u2010twins. The studies included in the meta\u2010analysis demonstrated small study effects and possible selection bias.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Preterm birth was the commonest adverse outcome affecting 58.5 and 53.7% of monochorionic and dichorionic twin pregnancies. Outcomes regarding brain imaging and neurodevelopmental comorbidity are an important area for future research, but meta\u2010analysis may be limited due to different methods of assessment.<\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n \n Preterm birth is the highest risk in single co\u2010twin death. Abnormal antenatal brain imaging was found in 1\/5 surviving\n MC<\/jats:styled-content>\n twins.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.15530","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T03:15:32Z","timestamp":1542770132000},"page":"569-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Prognosis of the co\u2010twin following spontaneous single intrauterine fetal death in twin pregnancies: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"FL","family":"Mackie","sequence":"first","affiliation":[{"name":"Centre for Women's and Children Health Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rigby","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RK","family":"Morris","sequence":"additional","affiliation":[{"name":"Centre for Women's and Children Health Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"},{"name":"West Midlands Fetal Medicine Centre Birmingham Women's and Children's NHS Foundation Trust Edgbaston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MD","family":"Kilby","sequence":"additional","affiliation":[{"name":"Centre for Women's and Children Health Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"},{"name":"West Midlands Fetal Medicine Centre Birmingham Women's and Children's NHS Foundation Trust Edgbaston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02215-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.8.2124"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17426"},{"key":"e_1_2_6_5_1","first-page":"541","article-title":"Intrauterine death of one fetus during the first trimester in multiple gestation","volume":"72","author":"Malinowski W","year":"2001","journal-title":"Ginekol Pol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01027.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822f129d"},{"key":"e_1_2_6_8_1","volume-title":"Multiple Pregnancy. 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