{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:57:06Z","timestamp":1773518226686,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T00:00:00Z","timestamp":1545696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470201"],"award-info":[{"award-number":["81470201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether maternal aspirin use during pregnancy is associated with childhood blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Setting<\/jats:title><jats:p>A secondary analysis of the Collaborative Perinatal Project, a prospective cohort study including 12 US academic medical centres between 1959 and 1976.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Singleton births among women with detailed medication information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out linear and multivariate logistic regression analysis to assess the associations between maternal aspirin exposure and childhood blood pressure at age 7 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Offspring blood pressure at age 7 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 793 women were exposed to aspirin 4 weeks before the last menstrual period or during pregnancy. In utero aspirin exposure may be associated with an 11% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.85\u2013 0.93) and a 20% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.76\u20130.84) reduced risk of having high systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) and diastolic blood pressure (<jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>) at 7 years of age, and a mean decrease of 0.62 mmHg for <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> and 1.04 mmHg for <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> at 7 years of age. Compared with children born to mothers without aspirin exposure, those whose mothers were exposed to aspirin for at least 7 days during pregnancy had approximately 10% and 27% reduced risk of high <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>, respectively, and a mean reduction of 0.61 and 1.27 mmHg in <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> at 7 years of age. The earlier the aspirin exposure occurred during pregnancy, the lower the risk of childhood high blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In utero exposure to aspirin may have long\u2010term benefits for childhood blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Maternal aspirin exposure might decrease the risk of childhood blood pressure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15561","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T16:08:56Z","timestamp":1543075736000},"page":"599-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of intrauterine exposure to aspirin and blood pressure at 7 years of age: a secondary analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"Y","family":"Chen","sequence":"first","affiliation":[{"name":"Department of 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