{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:30:02Z","timestamp":1792290602738,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the association of maternal anaemia with maternal, fetal, and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Rural India and Pakistan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Pregnant women residing in the study catchment area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an analysis of a prospective pregnancy registry in which haemoglobin is commonly obtained as well as maternal, fetal, and neonatal outcomes for 42\u00a0days post\u2010delivery. Women 40\u00a0years or older who delivered before 20\u00a0weeks or had a haemoglobin level of &lt;3.0\u00a0g\/dl were excluded. Our primary exposure was maternal anaemia, which was categorised in keeping with World Health Organization criteria based on a normal (\u226511\u00a0g\/dl), mild (&gt;10\u201310.9\u00a0g\/dl), moderate (7\u20139.9\u00a0g\/dl) or severe (&lt;7\u00a0g\/dl). haemoglobin level. The primary maternal outcome was maternal death, the primary fetal outcome was stillbirth, and the primary neonatal outcome was neonatal mortality &lt;28\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 92\u00a0247 deliveries and 93\u00a0107 infants were included, of which 87.8% were born to mothers who were anaemic (mild 37.9%, moderate 49.1%, and severe 0.7%). Maternal mortality (number per 100\u00a0000) was not associated with anaemia: normal 124, mild 106, moderate 135, and severe 325 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.64). Fetal and neonatal mortality was associated with severe anaemia: stillbirth rate (n\/1000)\u2014normal 27.7, mild 25.8, moderate 30.1, and severe 90.9; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001; 28\u2010day neonatal mortality (n\/1000)\u2014normal 24.7, mild 22.9, moderate 28.1, and severe 72.6 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Severe maternal anaemia was also associated with low birthweight (&lt;2500\u00a0and &lt;1500\u00a0g), preterm birth, and postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe maternal anaemia is associated with higher risks of poor maternal, fetal, and neonatal outcomes but other\u00a0degrees of anaemia are not. Interventions directed at preventing severe anaemia in pregnant women should be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Severe maternal anaemia is associated with adverse fetal and neonatal outcomes in low\/middle\u2010income countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15585","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T11:15:12Z","timestamp":1544958912000},"page":"737-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Maternal anaemia and maternal, fetal, and neonatal outcomes in a prospective cohort study in India and Pakistan"],"prefix":"10.1111","volume":"126","author":[{"given":"S","family":"Parks","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Christiana Care Health System Newark DE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MK","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Christiana Care Health System Newark DE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SS","family":"Goudar","sequence":"additional","affiliation":[{"name":"KLE Academy of Higher Education and Research Belgaum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Patel","sequence":"additional","affiliation":[{"name":"Lata Medical Research Foundation Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences Aga Khan University Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences Aga Khan University Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RL","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PL","family":"Hibberd","sequence":"additional","affiliation":[{"name":"Department of Global Health Boston University School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Moore","sequence":"additional","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wallace","sequence":"additional","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EM","family":"McClure","sequence":"additional","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RJ","family":"Derman","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.Prevalence of anaemia in pregnant women: Estimates by country [Internet]. 2017 [cited 2018 May 2]."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1280s"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2003.01178.x"},{"key":"e_1_2_6_5_1","first-page":"155","article-title":"Maternal hematologic levels and pregnancy outcomes","volume":"5","author":"Garn S","year":"1981","journal-title":"Semin Perinatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.590S"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/43.2.89"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00225-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.845161"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9508"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-015-0012-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.035659"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2003.11.045"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/cki219"},{"key":"e_1_2_6_15_1","first-page":"139","article-title":"Prevalence of anemia and correlated factors in the reproductive age women in rural areas of Tabas","volume":"7","author":"Sadeghian M","year":"2013","journal-title":"J Fam Reprod Heal"},{"key":"e_1_2_6_16_1","unstructured":"KhanM DastidarS SinghR.Nutrition and health practices among the rural women\u2014a case study of Uttar Pradesh India. 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Lancet Glob Health [Internet]. 2018 Mar 20 [cited 2018 Apr 2]; Available from:"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14961"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12862"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.15585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:22:33Z","timestamp":1693833753000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/1471-0528.15585"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15585","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"assertion":[{"value":"2018-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}