{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:27:14Z","timestamp":1788175634281,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether supraphysiological estradiol (E<jats:sub>2<\/jats:sub>) in controlled ovarian stimulation (<jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content>) cycles affects the subsequent frozen\u2010thawed embryo transfer (<jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>) in terms of the neonatal birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University affiliated hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 2066 patients undergoing <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> cycles that resulted in live singleton births between July 2011 and Dec 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multivariable linear regression and logistic regression was used to evaluate the association between peak E<jats:sub>2<\/jats:sub> and birthweight outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Birthweight, <jats:italic>z<\/jats:italic>\u2010score adjusted for gender and gestational age, and incidence of small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) and low birthweight (<jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content>) in singleton neonates derived from <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusted for confounding factors, both the absolute birthweight and the <jats:italic>z<\/jats:italic>\u2010score of singletons following <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> were negatively associated with peak E<jats:sub>2<\/jats:sub> levels in <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content>. In comparison with the referent category (E<jats:sub>2<\/jats:sub>\u00a0\u22641500\u00a0pg\/ml), the categories with E<jats:sub>2<\/jats:sub>\u00a0&gt;3000\u00a0pg\/ml had a significantly lower <jats:italic>z<\/jats:italic>\u2010score. The difference (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) in estimated marginal mean of birthweights between referent category and highest E<jats:sub>2<\/jats:sub> (&gt;8000\u00a0pg\/ml) category was 104.57 g (18.13\u2013181.06). Multiple logistic regression analyses showed that the adjusted odds ratio (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content> in term singletons comparing patients with E<jats:sub>2<\/jats:sub>\u00a0&gt;3000\u00a0pg\/ml with those with E<jats:sub>2<\/jats:sub>\u00a0\u22643000\u00a0pg\/ml was 2.44 (1.37\u20134.34) and 2.32 (1.01\u20135.40), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peak E<jats:sub>2<\/jats:sub> levels in <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content> cycles are negatively associated with the birthweight of singletons conceived through subsequent <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>The birthweight following <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> is affected by previous <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content> cycle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15606","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T07:42:42Z","timestamp":1547106162000},"page":"711-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Supraphysiological estradiol level in ovarian stimulation cycles affects the birthweight of neonates conceived through subsequent frozen\u2010thawed cycles: a retrospective study"],"prefix":"10.1111","volume":"126","author":[{"given":"J","family":"Cai","sequence":"first","affiliation":[{"name":"The Affiliated Chenggong Hospital of Xiamen University Xiamen China"},{"name":"Medical College of Xiamen University Xiamen 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