{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:13:36Z","timestamp":1770336816019,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["JGYXLJ1502"],"award-info":[{"award-number":["JGYXLJ1502"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15411968200"],"award-info":[{"award-number":["15411968200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFC0902902"],"award-info":[{"award-number":["2016YFC0902902"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To update the oncological results and identify recurrent risk factors in young patients with early stage cervical cancers following abdominal radical trachelectomy (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A university\u2010based cancer hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Three hundred and thirty\u2010three patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis from a prospectively maintained database of patients undergoing <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> from April 2004 to December 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Survival rate, clinicopathological factors related to recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and seventy\u2010one patients had squamous carcinomas (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>), 51 had pure adenocarcinomas (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>), and 11 had adenosquamous carcinomas (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>). One hundred thirty\u2010two women (39.6%) had tumours \u22652\u00a0cm. With a median follow up of 56\u00a0months (range, 6\u2013169), 11 patients (3.3%) had recurrence, and five patients (1.5%) died. The cumulative 5\u2010year recurrence\u2010free survival and overall survival rates were 96.3 and 98.6%, respectively. The recurrence rate in women with tumours \u22652\u00a0cm was comparable to that in patients with tumours &lt;2\u00a0cm (5.3 versus 2.0%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). However, the recurrence rate was significantly higher in patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> histology than those with <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> histology (18.2, 3.9, and 2.6%, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). All of the recurrent patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> histology had tumours \u22652\u00a0cm. Multivariate analysis showed that the only independent risk factor for recurrence was histology type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This updated series showed a favourable survival rate following <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>. These results further supported that <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> was a safe option for well\u2010selected patients with stage <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>1 cervical cancers \u22652\u00a0cm. However, if patients with tumours \u22652\u00a0cm have <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> histology, they should be advised with great caution when contemplating <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Abdominal radical trachelectomy could be a safe, fertility\u2010sparing option for strictly selected patients with stage <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>1\u2013<jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>1 cervical cancers \u22644\u00a0cm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15621","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T09:57:45Z","timestamp":1548064665000},"page":"1169-1174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Oncological results and recurrent risk factors following abdominal radical trachelectomy: an updated series of 333 patients"],"prefix":"10.1111","volume":"126","author":[{"given":"X","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynaecologic Oncology Fudan University Shanghai Cancer Centre Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Fudan University Shanghai Cancer Centre Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Radiology Fudan University Shanghai Cancer Centre Shanghai 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Fudan University Shanghai Cancer Centre Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"285","article-title":"La trachelectomie elargie (T.E.) une alternative \u00e0 l\u2018hysterectomie radicale dans le traitement des cancers infiltrants developpes sur la face externe du col uterin","volume":"2","author":"Dargent 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