{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:21:06Z","timestamp":1783074066936,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Pregnancies in women with Loeys\u2013Dietz syndrome (<jats:styled-content style=\"fixed-case\">LDS<\/jats:styled-content>) are rare and are typically documented in case reports only. Early reports suggested high rates of maternal complications during pregnancy and the puerperium, including aortic dissection and uterine rupture, but information on fetal outcomes was very limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Eight specialist <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Pregnant women with <jats:styled-content style=\"fixed-case\">LDS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data was collated on cardiac, obstetric, and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal and perinatal outcomes in pregnancies complicated by <jats:styled-content style=\"fixed-case\">LDS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty pregnancies in 13 women with <jats:styled-content style=\"fixed-case\">LDS<\/jats:styled-content> were identified. There was one miscarriage, one termination of pregnancy, and 18 livebirths. In eight women the diagnosis was known prior to pregnancy but only one woman had preconception counselling. In four women the diagnosis was made during pregnancy through positive genotyping, and the other was diagnosed following delivery. Five women had a family history of aortic dissection. There were no aortic dissections in our cohort during pregnancy or postpartum. Obstetric complications were common, including postpartum haemorrhage (33%) and preterm delivery (50%). In all, 14\/18 (78%) of deliveries were by elective caesarean section, at a median gestational age at delivery of 37 weeks. Over half the infants (56%) were admitted to the neonatal unit following delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">LDS<\/jats:styled-content> require multidisciplinary specialist management throughout pregnancy. Women should be referred for preconception counselling to make informed decisions around pregnancy risk and outcomes. Early elective preterm delivery needs to be balanced against a high infant admission rate to the neonatal unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Pregnancy outcomes in women with Loeys\u2013Dietz syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15670","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T01:46:22Z","timestamp":1551318382000},"page":"1025-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Maternal and fetal outcomes in pregnancies complicated by the inherited aortopathy Loeys\u2013Dietz syndrome"],"prefix":"10.1111","volume":"126","author":[{"given":"M","family":"Cauldwell","sequence":"first","affiliation":[{"name":"Academic Department of Obstetrics and Gynaecology Chelsea and Westminster Hospital London 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