{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:45Z","timestamp":1792788585483,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Objective<\/jats:title>\n To determine the effects on the vaginal microbiota of an oral probiotic preparation administered from early pregnancy.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Randomised, double blind, placebo\u2010controlled trial.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Four maternity units in the\n UK<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Women aged 16 years or older recruited at 9\u201314 weeks' gestation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Participants were randomly allocated to receive oral capsules of probiotic containing\n Lactobacillus rhamnosus<\/jats:italic>\n GR<\/jats:styled-content>\n \u20101 and\n Lactobacillus reuteri<\/jats:italic>\n RC<\/jats:styled-content>\n \u201014 each at 2.5 \u00d7 10\n 9<\/jats:sup>\n colony\u2010forming units (\n CFU<\/jats:styled-content>\n s) or placebo once daily from recruitment until the end of pregnancy.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measure<\/jats:title>\n \n Rates of bacterial vaginosis (\n BV<\/jats:styled-content>\n , defined as Nugent score \u22657) at 18\u201320 weeks' gestation compared by logistic regression adjusted for possible confounders.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The primary analysis included 78% (238\/304) of participants who initially consented (probiotic group 123, placebo group 115). Of these participants, 95% (227\/238) reported an intake of 93% or more of the required number of capsules. The rates of\n BV<\/jats:styled-content>\n did not differ between groups at 18\u201320 weeks' gestation (15% (19\/123) in the probiotic group vs. 9% (10\/115) in the placebo group, adjusted odds ratio 1.82, 95% confidence interval 0.64\u20135.19). There were also no differences between the groups in the proportion of women colonised with the probiotic strains,\n Escherichia coli,<\/jats:italic>\n group B streptococci or other vaginal microbiota. There were no differences in the alpha diversity or composition of the bacterial communities between or within the probiotic and placebo groups at 9\u201314 and 18\u201320 weeks\u2019 gestation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Oral probiotics taken from early pregnancy did not modify the vaginal microbiota.<\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n \n The oral probiotic preparation used in this study does not prevent\n BV<\/jats:styled-content>\n in pregnant women.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.15675","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T08:14:32Z","timestamp":1554106472000},"page":"275-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double\u2010blind, placebo\u2010controlled trial with microbiome analysis"],"prefix":"10.1111","volume":"127","author":[{"given":"S","family":"Husain","sequence":"first","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Blizard Institute Queen Mary University of London London UK"},{"name":"Neonatal Unit Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-6246","authenticated-orcid":false,"given":"J","family":"Allotey","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Drymoussi","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and the London School of Medicine and Dentistry Queen Mary University of London London 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