{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:51:48Z","timestamp":1779281508351,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["04152656"],"award-info":[{"award-number":["04152656"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of haemostatic sealant compared with bipolar coagulation on ovarian reserve after laparoscopic cystectomy for ovarian endometriomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Patient\u2010blinded, randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University\u2010affiliated tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women aged 18\u201340\u00a0years with 3\u20138\u00a0cm unilateral or bilateral endometriomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010four patients were randomised to receive haemostasis by the application of haemostatic sealant (<jats:italic>n<\/jats:italic>\u00a0=\u00a047) or standard care (<jats:italic>n<\/jats:italic>\u00a0=\u00a047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Primary outcome was the effect on the antral follicular count 3\u00a0months after the operation as it captures the effect on the ovary subjected to treatment. Secondary outcomes included the change in anti\u2010Mullerian hormone, follicular\u2010stimulating hormone and peri\u2010operative outcomes including haemostasis, complications, pain, and satisfaction scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 94 patients aged 32.36\u00a0\u00b1\u00a04.92\u00a0years underwent laparoscopic cystectomy for ovarian endometriomas. The average diameter of the endometrioma was 4.21\u00a0\u00b1\u00a01.38\u00a0cm. The increase in antral follicle count of the affected ovaries at 3\u00a0months in the intervention group (+2.36\u00a0\u00b1\u00a00.37) was significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013) higher than that in the control group (+1.08\u00a0\u00b1\u00a00.36). Repeated measures analysis of variance revealed significant effect with time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and of interaction of group\u00a0\u00d7\u00a0time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029) for affected ovary antral follicle count. No significant difference was noted between the two groups with regard to follicular\u2010stimulating hormone, anti\u2010Mullerian hormone, and other secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Applying haemostatic sealant after laparoscopic cystectomy of ovarian endometriomas produced a greater increase in antral follicle count 3\u00a0months after surgery compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>: Haemostatic sealant in laparoscopic cystectomy of endometriomas increase in the antral follicle count after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15807","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T02:56:29Z","timestamp":1556679389000},"page":"1267-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of haemostatic sealant versus electrocoagulation on ovarian reserve after laparoscopic ovarian cystectomy of ovarian endometriomas: a randomised controlled trial"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-578X","authenticated-orcid":false,"given":"JPW","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong, SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TSM","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong, SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHS","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong, SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-6078","authenticated-orcid":false,"given":"JSM","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong, SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DS","family":"Sahota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong, SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TC","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong, SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.01.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi049"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000084247.09900.4f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200008000-00008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12056"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.056"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.05.029"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.04.006"},{"key":"e_1_2_7_11_1","unstructured":"Baxter Healthcare Corporation.FloSeal haemostatic matrix instructions for use. 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