{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T16:01:34Z","timestamp":1769443294041,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare effectiveness of spontaneous ovulation monitored by urinary luteinising hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) versus induced ovulation by administration of human chorionic gonadotrophin (<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>) in couples undergoing gonadotrophin\u2010stimulated intrauterine insemination (<jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University\u2010level infertility unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Couples with unexplained infertility, mild endometriosis, mild male factor infertility and polycystic ovarian syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Couples were randomised to an <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> group (Group A), in which urinary <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> was measured daily to detect spontaneous ovulation, or an <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> group (Group B), in which urinary <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> was administered as a trigger.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Clinical pregnancy rate. Secondary outcomes\u00a0\u2013\u00a0ongoing pregnancy, live birth, multiple pregnancy and miscarriage rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 392 couples were randomised with 196 in each arm. The clinical pregnancy rate per woman randomised was 14\/196 (7.1%) in the <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> arm versus 15\/196 (7.6%) in the <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> arm (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.847, which was not statistically significant). Similarly, the ongoing pregnancy rates [13\/196 (6.6%) versus 14\/196 (7.1%); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.84] and the live birth rates [13\/196 (6.6%) versus 14\/196 (7.1%); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.84] between the two groups did not show any significant difference. The duration of stimulation and gonadotrophin dosage also did not differ significantly between the two methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no significant difference in clinical pregnancy rates when urinary <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> trigger were compared as methods to time insemination in women undergoing gonadotropin\u2010stimulated <jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A randomised controlled study showing similar effectiveness between two different methods of timing <jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15830","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T13:59:19Z","timestamp":1559829559000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of spontaneous ovulation as monitored by urinary luteinising hormone versus induced ovulation by administration of human chorionic gonadotrophin in couples undergoing gonadotrophin\u2010stimulated intrauterine insemination: a randomised controlled trial"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-5384","authenticated-orcid":false,"given":"S","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Christian Medical College Vellore 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