{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:54:42Z","timestamp":1774500882166,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Municipal Science and Technology","award":["Z171100001017030"],"award-info":[{"award-number":["Z171100001017030"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of intermittent intrauterine balloon dilatation versus standard care in the prevention of adhesion reformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010blind randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Hysteroscopic Centre of a tertiary University Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Two hundred patients with moderate to severe (European Society for Gynaecological Endoscopy Grade \u2265<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) intrauterine adhesions who underwent hysteroscopic adhesiolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants were randomised to a balloon group or a control group postoperatively. The balloon group received intrauterine balloon dilatation therapy at 2\u00a0weeks and 6\u00a0weeks after surgery, whereas the control group did not. All patients underwent follow\u2010up hysteroscopy at 4 and 8\u00a0weeks postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The adhesion reformation rate and the Pictorial Blood Loss Assessment Chart scores were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 191 patients successfully completed the study protocol (94 cases for the balloon group and 97 cases for the control group). According to hysteroscopic evaluation at the 8th week, the overall adhesion reformation rate was significantly lower in patients in the balloon group than patients in the control group (20.2% versus 40.2%, respectively; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). There was also a significant increase in menstruation flow, as assessed by the Pictorial Blood Loss Assessment Chart score (30 versus 9, respectively; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative intermittent intrauterine balloon dilatation therapy can significantly reduce postoperative adhesion reformation and significantly increase menstruation flow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>: Postoperative intermittent intrauterine balloon therapy can prevent adhesion reformation after hysteroscopic adhesiolysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15843","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T17:18:37Z","timestamp":1560791917000},"page":"1259-1266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Prevention of postoperative adhesion reformation by intermittent intrauterine balloon therapy: a randomised controlled trial"],"prefix":"10.1111","volume":"126","author":[{"given":"X","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Hysteroscopic Centre Fuxing Hospital the Eighth Clinical Medical College Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SH","family":"Saravelos","sequence":"additional","affiliation":[{"name":"IVF Unit Hammersmith Hospital Imperial College London UK"},{"name":"Assisted Conception Unit Department of Obstetrics and Gynaecology Prince of Wales 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