{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:42:53Z","timestamp":1771047773054,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the risk of inducing RhD immunisation in pregnancies of RhD\u2010negative mothers with an RhD\u2010positive fetus undergoing chorionic villus samplings (<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>) or amniocenteses (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, setting and population<\/jats:title><jats:p>Registry\u2010based study in a Danish cohort which has not been given rhesus prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrieved from the Department of Clinical Immunology at Rigshospitalet. All RhD\u2010negative women carrying an RhD\u2010positive fetus with screen test results from weeks 8\u201312 and weeks 25\u201329 were linked to data from the Danish Fetal Medicine Database. Data were divided into cases where no invasive prenatal diagnostic procedure was performed, cases that had <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> performed, and cases that had <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content> performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>A comparison of the proportion of women who developed RhD immunisation between the two screen tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort consisted of 10\u00a0085 women: 9353 had no invasive procedures performed, 189 had <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and 543 had <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content> performed. No women were immunised spontaneously or due to the procedure between the first and second screen test in the group with no procedure performed, or in the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> group. One woman was immunised in the <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content> group. When comparing the proportion of women who was immunised in the <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content> group with the no invasive test group a non\u2010significant difference was found (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.055).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RhD immunisation rate before gestational weeks 25\u201329 in RhD\u2010negative women carrying an RhD\u2010positive fetus is very low, even in women undergoing prenatal invasive testing without rhesus prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>The RhD immunisation rate during pregnancy is very low even in women undergoing prenatal invasive testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15861","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T13:29:44Z","timestamp":1562592584000},"page":"1476-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Do chorionic villus samplings (<scp>CVS<\/scp>) or amniocenteses (<scp>AC<\/scp>) induce RhD immunisation? 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