{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:08:46Z","timestamp":1791889726737,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Risk of fetotoxicity after paracetamol exposure in the third trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational cohort study and retrospective case assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Germany, 2008\u20132017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Pregnant women exposed to paracetamol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospectively enrolled third\u2010trimester pregnancies that had been exposed to paracetamol (604) were compared with pregnancies exposed to paracetamol in the first and\/or second trimester only (1192). Exclusion criteria were exposure to nonsteroidal anti\u2010inflammatory drugs (\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s) in the second or third trimester. Additionally, the Embryotox \u2018adverse drug reaction in pregnancy\u2019 database was screened for cases of fetotoxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The prenatal study end points focused on narrowing or closure of ductus arteriosus Botalli, late fetal death, and oligohydramnios. The postnatal end points included patent ductus arteriosus (PDA), primary pulmonary hypertension (PPHT), and impaired renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In both cohorts, no fetus with intrauterine narrowing or closure of the ductus arteriosus Botalli was reported (0\/604 versus 0\/1192). Oligohydramnios was diagnosed at a similar frequency in both cohorts: 1.3% (8\/604) versus 1.6% (19\/1192). There was one stillbirth in the study cohort (1\/604, 0.2%) and four stillbirths in the comparison cohort (4\/1192, 0.3%). The rates of PDA in neonates were similar: 0.7% (4\/615) versus 0.7% (9\/1212). PPHT as well as serious postnatal renal disorders were reported once in each cohort. In 12 out of 96 retrospective cases, there were indicators for study end points; however, co\u2010exposure to\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s or complex situations weaken the assumption of paracetamol toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fetal cardiovascular or renal toxicity of maternal third\u2010trimester paracetamol use appears to be negligible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Paracetamol use in the third trimester does not seem to be associated with a relevant risk of fetotoxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.15872","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T12:15:10Z","timestamp":1563279310000},"page":"1560-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third\u2010trimester paracetamol use: evaluation of the German Embryotox cohort"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-5817","authenticated-orcid":false,"given":"K","family":"Dathe","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Institut f\u00fcr Klinische Pharmakologie und Toxikologie Pharmakovigilanz- und Beratungszentrum f\u00fcr Embryonaltoxikologie Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Frank","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Institut f\u00fcr Klinische Pharmakologie und Toxikologie Pharmakovigilanz- und Beratungszentrum f\u00fcr Embryonaltoxikologie Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Padberg","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Institut f\u00fcr Klinische Pharmakologie und Toxikologie Pharmakovigilanz- und Beratungszentrum f\u00fcr Embryonaltoxikologie Berlin 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