{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T15:15:07Z","timestamp":1771168507824,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the 5\u2010year risk of high\u2010grade lesions in women with a transient high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> primary testing within population\u2010based organised cervical cancer screening programmes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Italian women enrolled in seven pilot projects and attending the second round.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On the basis of the cytology triage performed on <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive women, immediate colposcopy or <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> repeat at 12\u00a0months was recommended. Data were collected at the subsequent round 3\u20134\u00a0years after <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Rates of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection, <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ and <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+ detection at subsequent round after <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> clearance, and relative risks (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) in comparison with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010negative women (with 95% confidence interval).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data on 1230 women (1027 aged 25\u201364\u00a0years and 203 aged 35\u201364\u00a0years) have been analysed. Overall compliance with repeat <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing was 84%. In comparison with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010negative women, those with a transient <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection had higher proportions of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity (15% versus 3.7%) and of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ lesions (0.87% versus 0.23%) in round two; most of these (7\/10) were <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2; no cancers were detected, and <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 occurred in 3\/1230 (0.24%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010based protocols for cervical cancer screening allow long intervals for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010negative women; it is important to monitor the clinical outcome in the women with transient high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection. <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 detection is similar to that observed in routine European cytology\u2010based screening programmes (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+: 2.7\u2030); 5\u2010year intervals may provide reasonable protection but longer intervals are not recommended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A screening interval of 5\u00a0years (but no longer) appears safe in women with transient <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> detection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15893","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T17:03:31Z","timestamp":1564419811000},"page":"1365-1371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Five\u2010year risk of <scp>CIN<\/scp>3 after short\u2010term <scp>HPV<\/scp>\u2010<scp>DNA<\/scp> negativity in cytology\u2010negative women: a population\u2010based cohort study"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-9374","authenticated-orcid":false,"given":"A","family":"Del Mistro","sequence":"first","affiliation":[{"name":"Immunology and Diagnostic Molecular Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Giorgi Rossi","sequence":"additional","affiliation":[{"name":"Epidemiology Unit Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Frayle","sequence":"additional","affiliation":[{"name":"Immunology and Diagnostic Molecular Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Pasquale","sequence":"additional","affiliation":[{"name":"Ex\u2010ASL Vallecamonica\u2010Sebino Regione Lombardia, Sulzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Campari","sequence":"additional","affiliation":[{"name":"Cancer Screening Unit Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ronco","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, Infection and Cancer Epidemiology Unit Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry Azienda Zero Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume-title":"Cervix Cancer Screening. 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