{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:13:45Z","timestamp":1781770425743,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002981","name":"Milj\u00f8ministeriet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The Japan Environment and Children's Study (<jats:styled-content style=\"fixed-case\">JECS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 94\u00a0349 singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non\u2010drinkers, consumers of 1\u2013149\u00a0g, 150\u2013299\u00a0g and \u2265300\u00a0g ethanol\/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> were calculated relative to non\u2010drinkers using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Medical record\u2010based preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (\u2265300\u00a0g ethanol\/week) during the second and third trimesters was associated with a four\u2010fold higher risk compared with non\u2010drinkers (multivariable <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.52; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.68\u201312.2). Light alcohol consumption (1\u2013149\u00a0g ethanol\/week) tended to be associated with lower risk of preterm delivery (multivariable <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.78; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.60\u20131.00).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Heavy drinking during pregnancy may increase the risk of preterm delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15899","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T12:55:34Z","timestamp":1565096134000},"page":"1448-1454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study"],"prefix":"10.1111","volume":"126","author":[{"given":"S","family":"Ikehara","sequence":"first","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine Suita\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Public Health Hokkaido University Graduate School of Medicine Sapporo 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