{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:12:15Z","timestamp":1790845935831,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate incidence, trends over time, and risk factors for massive blood transfusions in obstetric patients. A secondary aim was to evaluate transfusion ratios in relation to massive transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Five hospitals, in the Stockholm County, Sweden, from 1990 to 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>All women that gave birth in Stockholm county, Sweden, and who received blood transfusions postpartum between 1990 and 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on pregnancies and deliveries from the Swedish National Medical Birth Registry was cross\u2010linked to the Stockholm transfusion database. Massive blood transfusion was defined as the transfusion of \u226510 units of red blood cells from partus through the next day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Main primary outcome was massive blood transfusion postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our cohort comprised 517\u00a0874 deliveries. Massive blood transfusion occurred in 277 women, for an incidence of 5.3 per 10\u00a0000 deliveries, and increased by 30% (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) between the first and the second half of the study period. Major risk factors apparent before delivery were abnormal placentation (<jats:styled-content style=\"fixed-case\">odds ratio [OR]<\/jats:styled-content> 41; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 29.3\u201358.1), pre\u2010eclampsia\/placental abruption (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.8\u20135.6), and previous caesarean delivery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.1\u20136.0). Risk factors at time of delivery were uterine rupture, atonic uterus, and caesarean delivery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 38, 17, and 3, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found an increasing trend in the postpartum rate of massive transfusion. Women with abnormal placentation were found to have the highest increased risk. Improved antenatal awareness of these women at risk might improve management and reduce the rate of massive transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Risk of massive blood transfusion in obstetric patients increases with placental complications and prior caesarean section.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15927","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T18:09:35Z","timestamp":1567620575000},"page":"1577-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Massive blood transfusion in relation to delivery: incidence, trends and risk factors: a population\u2010based cohort study"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-029X","authenticated-orcid":false,"given":"L","family":"Thurn","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology CLINTEC Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wikman","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital and Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Westgren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology CLINTEC Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8235","authenticated-orcid":false,"given":"PG","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Education Karolinska Institutet Stockholm Sweden"},{"name":"Department of Obstetrics and Gynaecology S\u00f6dersjukhuset Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Managing Complications in Pregnancy and Childbirth","author":"World Health Organization","year":"2000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000199549.80731.e6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06355.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e328342310e"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000021"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13831"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001410"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11454.x"},{"key":"e_1_2_6_11_1","first-page":"1002","article-title":"Blood transfusion for primary postpartum hemorrhage: a tertiary care hospital review","volume":"30","author":"Balki M","year":"2008","journal-title":"JOGC"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03198.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-55"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181d74898"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12950"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.10.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.03.002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12150"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32830f1fd1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6892.2004.00453.x"},{"key":"e_1_2_6_22_1","volume-title":"The Swedish Medical Birth Register\u2014A Summary of Content and Quality","author":"The National Board of Health, Sweden","year":"2003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01147.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14952"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13389"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182051db2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.02.016"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13547"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.553695"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000219750.79480.84"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.074"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12644"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2237-3"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.10.038"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1384-7"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00686.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14178"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03409.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2011.04.002"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000184"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2012.03.005"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04972.x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.15927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T23:38:32Z","timestamp":1694129912000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":42,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/1471-0528.15927"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15927","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,23]]},"assertion":[{"value":"2019-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}