{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:59:19Z","timestamp":1789156759497,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate if the intraoperative human papillomavirus (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) test has the same prognostic value as the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test performed at 6\u00a0months after treatment of high\u2010grade squamous intraepithelial lesion (<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>) to predict treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Barcelona, Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 216 women diagnosed with <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> and treated with loop electrosurgical excision procedure (<jats:styled-content style=\"fixed-case\">LEEP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After <jats:styled-content style=\"fixed-case\">LEEP<\/jats:styled-content>, an <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test was performed using the Hybrid Capture 2 system. If this was positive, genotyping was performed with the <jats:styled-content style=\"fixed-case\">CLART HPV<\/jats:styled-content>2 technique. The <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test was compared with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test at 6\u00a0months and with surgical margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recurrence rate of <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> was 6%. There was a strong association between a positive <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test, a positive 6\u2010month <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test, positive <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u00a016 genotype, positive surgical margins and <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> recurrence. Sensitivity, specificity, and positive and negative predictive values of the <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test were 85.7, 80.8,24.0 and 98.8% and of the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test at 6\u00a0months were 76.9, 75.8, 17.2 and 98.0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intraoperative HPV test accurately predicts treatment failure in women with cervical intraepithelial neoplasia grade 2\/3. This new approach may allow early identification of patients with recurrent disease, which will not delay the treatment. Genotyping could be useful in detecting high\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test accurately predicts treatment failure in women with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\u00a02\/3.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15932","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T07:15:45Z","timestamp":1568099745000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of the intraoperative human papillomavirus test as a marker of early cure at 12\u00a0months after electrosurgical excision procedure in women with cervical high\u2010grade squamous intraepithelial lesion: a prospective cohort 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