{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:49:31Z","timestamp":1791992971466,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the predictive value (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) of known prognostic factors of fetal infection with <jats:italic>Cytomegalovirus<\/jats:italic> following maternal primary infection &lt;14\u00a0weeks of gestation, at different time points of pregnancy: the end of the second trimester; following prenatal magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) at 32\u00a0weeks of gestation; and using all ultrasound scans performed in the third trimester (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>3rdT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Reference fetal medicine unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Sixty\u2010two fetuses infected &lt;14\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We defined second\u2010trimester assessment (<jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>) as the combination of ultrasound findings &lt;28\u00a0weeks of gestation and fetal platelet count at cordocentesis. Three groups were defined: normal, extracerebral, and cerebral <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>For each group, the <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content> alone, <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>3rdT were assessed retrospectively. Outcome at birth and at follow\u2010up were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content> was normal, and with extracerebral and cerebral features, in 43.5, 42.0, and 14.5%, respectively. The negative <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> of normal <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for moderate to severe sequelae was 100%. The residual risk was unilateral hearing loss in 16.7% of cases. Of pregnancies with cerebral <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>, 44% were terminated. Following extracerebral <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>, 48% of neonates were symptomatic and 30% had moderate to severe sequelae. In those cases, the positive and negative <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for sequelae were 33 and 73%, respectively. <jats:styled-content style=\"fixed-case\">STA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>3rdT had a lower negative <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for symptoms at birth and for moderate to severe sequelae. Any false\u2010positive findings at <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> were mostly the result of hypersignals of white matter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serial assessment in the second and third trimesters by ultrasound and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is necessary to predict the risk of sequelae occurring in 35% of pregnancies following fetal infection in the first trimester of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Serial ultrasound prognostic assessment following fetal <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection in the 1st trimester is improved by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> at 32\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15935","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T17:48:43Z","timestamp":1568137723000},"page":"355-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Refining the prognosis of fetuses infected with <i>Cytomegalovirus<\/i> in the first trimester of pregnancy by serial prenatal assessment: a single\u2010centre retrospective study"],"prefix":"10.1111","volume":"127","author":[{"given":"V","family":"Faure\u2010Bardon","sequence":"first","affiliation":[{"name":"EA 73\u201028 Paris Descartes University Sorbonne Paris Cit\u00e9 Paris France"},{"name":"Maternity H\u00f4pital Necker \u2013 Enfants Malades Assistance Publique \u2013 H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010E","family":"Millischer","sequence":"additional","affiliation":[{"name":"EA 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