{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:21:44Z","timestamp":1788438104789,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine variations in cord blood gas (CBG) parameters after 3\u2010minute delayed cord clamping (DCC) in vaginal deliveries (VDs) and caesarean deliveries (CDs) at term without fetal distress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>CBG from 97 VDs and 124 CDs without fetal distress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comparison of paired arterial\u2013venous CBG parameters drawn at birth from the unclamped cord and after 3\u2010minutes DCC for VDs and CDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Base excess, bicarbonate, haematocrit and haemoglobin from both arterial and venous cord blood, lactate, neonatal outcomes, partial pressure of oxygen (pO<jats:sub>2<\/jats:sub>), partial pressure of carbon dioxide (pCO<jats:sub>2<\/jats:sub>), pH, and postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arterial cord blood pH, bicarbonate (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bjo16026-math-0001.png\" xlink:title=\"urn:x-wiley:14700328:media:bjo16026:bjo16026-math-0001\"\/>, mmol\/l), and base excess (BE, mmol\/l) decreased significantly after 3\u2010minute DCC both in VDs (pH\u00a0=\u00a07.23 versus 7.27; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bjo16026-math-0002.png\" xlink:title=\"urn:x-wiley:14700328:media:bjo16026:bjo16026-math-0002\"\/>\u00a0=\u00a023.3 versus 24.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004; BE\u00a0=\u00a0\u22125.1 versus \u22122.9; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and CDs (pH\u00a0=\u00a07.28 versus 7.34; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bjo16026-math-0003.png\" xlink:title=\"urn:x-wiley:14700328:media:bjo16026:bjo16026-math-0003\"\/>\u00a0=\u00a026.2 versus 27.2; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; BE\u00a0=\u00a0\u22121.5 versus 0.7; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). After 3\u2010minute DCC, pCO<jats:sub>2<\/jats:sub> increased in CDs only (57 versus 51; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), whereas lactate increased more in CDs compared with VDs (lactate, +1.1 [0.9, 1.45] versus +0.5 [\u22120.65, 2.35]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Postpartum maternal haemorrhage, neonatal maximum bilirubin concentration, and need for phototherapy were similar between the two groups. Newborns born by CD more frequently required postnatal clinical monitoring or admission to a neonatal intensive care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After 3\u2010minute DCC, the acid\u2013base status shifted towards mixed acidosis in CDs and prevalent metabolic acidosis in VDs. CDs were associated with a more pronounced increase in arterial lactate, compared with VDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>By 3\u2010minute DCC, acid\u2013base status shifts towards mixed and metabolic acidosis in caesarean and vaginal delivery, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16026","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T05:44:26Z","timestamp":1574660666000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effect of delayed umbilical cord clamping on cord blood gas analysis in vaginal and caesarean\u2010delivered term newborns without fetal distress: a prospective observational study"],"prefix":"10.1111","volume":"127","author":[{"given":"N","family":"Giovannini","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fondazione IRCCS 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