{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:46:18Z","timestamp":1785851178065,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the association between maternal lipaemia and neonatal anthropometrics in Malaysian mother\u2013offspring pairs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single tertiary multidisciplinary antenatal clinic in Malaysia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 507 mothers: 145 with gestational diabetes mellitus (GDM); 94 who were obese with normal glucose tolerance (NGT) (pre\u2010gravid body mass index, BMI\u00a0\u2265\u00a027.5\u00a0kg\/m<jats:sup>2<\/jats:sup>), and 268 who were not obese with NGT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal demographic, anthropometric, and clinical data were collected during an interview\/examination using a structured questionnaire. Blood was drawn for insulin, C\u2010peptide, triglyceride (Tg), and non\u2010esterified fatty acid (NEFA) during the 75\u2010g 2\u2010hour oral glucose tolerance test (OGTT) screening, and again at 36\u00a0weeks of gestation. At birth, neonatal anthropometrics were assessed and data such as gestational weight gain (GWG) were extracted from the records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Macrosomia, large\u2010for\u2010gestational\u2010age (LGA) status, cohort\u2010specific birthweight (BW), neonatal fat mass (NFM), and sum of skinfold thickness (SSFT)\u00a0&gt;\u00a090th centile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting Tg\u00a0&gt;\u00a095th centile (3.6\u00a0mmol\/L) at screening for OGTT was independently associated with LGA (adjusted odds ratio, aOR 10.82, 95%\u00a0CI 1.26\u201393.37) after adjustment for maternal glucose, pre\u2010gravid BMI, and insulin sensitivity. Fasting glucose was independently associated with a birthweight ratio (BWR) of &gt;90th centile (aOR 2.06, 95%\u00a0CI 1.17\u20133.64), but not with LGA status, in this well\u2010treated GDM cohort with pre\u2010delivery HbA1c of 5.27%. In all, 45% of mothers had a pre\u2010gravid BMI of &lt;23\u00a0kg\/m<jats:sup>2<\/jats:sup> and 61% had a pre\u2010gravid BMI of \u2264\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>, yet a GWG of &gt;10\u00a0kg was associated with a 4.25\u2010fold risk (95%\u00a0CI 1.71\u201310.53) of BWR\u00a0&gt;\u00a090th centile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal lipaemia and GWG at a low threshold (&gt;10\u00a0kg) adversely impact neonatal adiposity in Asian offspring, independent of glucose, insulin resistance and pre\u2010gravid BMI. These may therefore be important modifiable metabolic targets in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Maternal lipids are associated with adiposity in Asian babies independently of pre\u2010gravid BMI, GDM status, and insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16031","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T14:09:40Z","timestamp":1574950180000},"page":"490-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Maternal lipids are associated with newborn adiposity, independent of GDM status, obesity and insulin resistance: a prospective observational cohort study"],"prefix":"10.1111","volume":"127","author":[{"given":"S","family":"Samsuddin","sequence":"first","affiliation":[{"name":"Endocrine Unit Department of Medicine University Malaya Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Endocrine Unit Department of Medicine University Malaya Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.S","family":"Md. 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