{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:09:06Z","timestamp":1792084146137,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a core outcome set for trials on the treatment of hyperemesis gravidarum (HG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Identification of outcomes is followed by a modified Delphi survey combined with a consensus development meeting and a consultation round.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An international web\u2010based survey combined with a consensus development meeting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Stakeholders including researchers; women with lived experience of HG and their families; obstetric health professionals; and other health professionals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used systematic review, semi\u2010structured patient interviews, closed group sessions and Steering Committee input to identify potential core outcomes. We conducted two web\u2010based survey rounds, followed by a face\u2010to\u2010face consensus development meeting and a web\u2010based consultation round.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>A core outcome set for research on HG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six potential outcomes were identified. The modified Delphi process was completed by 125 stakeholders, the consensus development meeting by 20 stakeholders and the consultation round by 96 stakeholders. Consensus was reached in ten domains on 24 outcomes: nausea; vomiting; inability to tolerate oral fluids or food; dehydration; weight difference; electrolyte imbalance; intravenous fluid treatment; use of medication for hyperemesis gravidarum; hospital treatment; treatment compliance; patient satisfaction; daily functioning; maternal physical or mental or emotional wellbeing; short\u2010 and long\u2010term adverse effects of treatment; maternal death; pregnancy complications; considering or actually terminating a wanted pregnancy; preterm birth; small for gestational age; congenital anomalies; neonatal morbidity and offspring death).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This core outcome set will help standardise outcome reporting in HG trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A core outcome set for treatment of hyperemesis gravidarum in order to create high\u2010quality evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16172","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T07:31:57Z","timestamp":1581665517000},"page":"983-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["A core outcome set for hyperemesis gravidarum research: an international consensus study"],"prefix":"10.1111","volume":"127","author":[{"given":"LAW","family":"Jansen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Academic Medical Centre Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynaecology Franciscus Gasthuis Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MH","family":"Koot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van\u2018t Hooft","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CR","family":"Dean","sequence":"additional","affiliation":[{"name":"Pregnancy Sickness Support Bodmin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JMN","family":"Duffy","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2115","authenticated-orcid":false,"given":"W","family":"Ganzevoort","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Academic Medical Centre Amsterdam the 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