{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:33:15Z","timestamp":1790307195801,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between a history of placental bed disorders and later dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>All women giving birth in Sweden between 1973 and 1993 (1\u00a0128\u00a0709).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with and without placental bed disorders (hypertensive disorders of pregnancy including pre\u2010eclampsia, fetal growth restriction, spontaneous preterm labour and birth, preterm premature rupture of membranes, abruptio placenta, late miscarriages) and other pregnancy complications were identified by means of the Swedish Medical Birth Register. International classification of disease was used. Data were linked to other National Registers. Participants were followed up until 2013. The Cox proportional hazards model was used to calculate hazard ratios for women with and without pregnancy complications and were adjusted for possible confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Diagnosis of vascular dementia and non\u2010vascular dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusted for cardiovascular disease and socio\u2010demographic factors, an increased risk of vascular dementia was shown in women with previous pregnancy\u2010induced hypertension (Hazard ratio [HR] 1.88, 95% CI 1.32\u20132.69), pre\u2010eclampsia (HR 1.63, 95% CI 1.23\u20132.16), spontaneous preterm labour and birth (HR 1.65, 95% CI 1.12\u20132.42) or preterm premature rupture of membranes (HR 1.60, 95% CI 1.08\u20132.37). No statistically significant increased risk was seen for other pregnancy complications or non\u2010vascular dementia even though many of the point estimates indicated increased risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with placental bed disorders have a higher risk for vascular disease. Mechanisms behind the abnormal placentation remain elusive, although maternal constitutional factors, abnormal implantation as well as impaired angiogenesis have been suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Placental bed syndromes associated with vascular dementia even after adjusting for cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16201","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T16:19:25Z","timestamp":1583597965000},"page":"1090-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prior placental bed disorders and later dementia: a retrospective Swedish register\u2010based cohort study"],"prefix":"10.1111","volume":"127","author":[{"given":"E","family":"Andolf","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynaecology Department of Clinical Sciences Karolinska Institutet Danderyd Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bladh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, and Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, and Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sydsj\u00f6","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, and Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9762-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003497"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0130-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03406.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.01.042"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182583070"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.044"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439043"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009880"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001534"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13096"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4109"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06357"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"e_1_2_6_19_1","unstructured":"National Board of Health and Welfare Centre for Epidemiology.The Swedish Medical Birth Register; A summary of content and quality (Article no. 2003\u2013112\u20103). 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