{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:41:39Z","timestamp":1792154499425,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the demographics, natural history and treatment outcomes of non\u2010molar gestational choriocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective national population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>UK 1995\u20132015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 234 women with a diagnosis of gestational choriocarcinoma, in the absence of a prior molar pregnancy, managed at the UKs two gestational trophoblast centres in London and Sheffield.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of the patient\u2019s demographic and clinical data. Comparison with contemporary UK birth and pregnancy statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes<\/jats:title><jats:p>Incidence statistics for non\u2010molar choriocarcinoma across the maternal age groups. Cure rates for patients by FIGO prognostic score group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 21\u2010year study period, there were 234 cases of non\u2010molar gestational choriocarcinoma, giving an incidence of 1:66\u00a0775 relative to live births and 1:84\u00a0226 to viable pregnancies. For women aged under 20, the incidence relative to viable pregnancies was 1:223\u00a0494, for ages 30\u201334, 1:80\u00a0227, and for ages 40\u201345, 1:41\u00a0718. Treatment outcomes indicated an overall 94.4% cure rate. Divided by FIGO prognostic groups, the cure rates were low\u2010risk group 100%, high\u2010risk group 96% and ultra\u2010high\u2010risk group 80.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010molar gestational choriocarcinoma is a very rare diagnosis with little prior detailed information on the demographics and natural history. The data in this study give age\u2010related incidence data based on a large national population study. The results also demonstrated the widely varying natural history of this rare malignancy and the marked correlation of disease incidence with rising maternal age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>National gestational choriocarcinoma database indicates a close association between increasing maternal age and incidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16202","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T01:04:41Z","timestamp":1583629481000},"page":"1102-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Demographics, natural history and treatment outcomes of non\u2010molar gestational choriocarcinoma: a UK population 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