{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:04:22Z","timestamp":1790438662808,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008340","name":"Elsass Fonden","doi-asserted-by":"publisher","award":["19\u20103\u20100457"],"award-info":[{"award-number":["19\u20103\u20100457"]}],"id":[{"id":"10.13039\/501100008340","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ordinary meta\u2010analyses indicate that magnesium sulphate (MgSO<jats:sub>4<\/jats:sub>) treatment in women at imminent risk for preterm delivery decreases the offspring's risk of cerebral palsy (CP). However, repetitive testing of cumulative data calls for statistical caution, e.g. by trial sequential analysis (TSA), for which there are previously insufficient samples to draw a firm conclusion. Recently, a randomised controlled trial (RCT) provided additional data that potentially increased the sample size such that a new TSA might detect a statistically significant effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the possible fetal neuroprotective effect of MgSO<jats:sub>4<\/jats:sub>for women at imminent risk for preterm delivery in an updated systematic review with meta\u2010analysis and TSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>We searched MEDLINE, Embase, Cochrane and<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>on 8 October 2019. The search strategy clustered terms describing the MgSO<jats:sub>4<\/jats:sub>intervention and preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>RCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Two reviewers extracted the data. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using fixed\u2010effects models. A TSA was applied to the primary outcome, CP. The quality of the evidence was assessed using\u00a0GRADE. The protocol was registered in PROSPERO (registration: CRD42019151441).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>We identified six eligible trials (5917 women). MgSO<jats:sub>4<\/jats:sub>intervention in women at imminent risk for preterm birth decreased the offspring's CP risk (meta\u2010analysis RR 0.68, 95% CI 0.54\u20130.85; TSA RR 0.69, 95% CI 0.48\u20130.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review with meta\u2010analysis and TSA shows conclusively that MgSO<jats:sub>4<\/jats:sub>, when given to women at imminent risk for preterm delivery, decreases the offspring's CP risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Antenatal magnesium sulphate decreases the risk of cerebral palsy in children born preterm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16238","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T06:36:09Z","timestamp":1585722969000},"page":"1180-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta\u2010analysis and trial sequential analysis"],"prefix":"10.1111","volume":"127","author":[{"given":"HT","family":"Wolf","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LD","family":"Huusom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TB","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics (Intensive Care Neonatology) Aarhus University Hospital Aarhus Denmark"},{"name":"Perinatal Epidemiology Research Unit Department of Paediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HK","family":"Hegaard","sequence":"additional","affiliation":[{"name":"The Research Unit Women's and Children's Health The Juliane Marie Centre Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Brok","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine University of Copenhagen Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pinborg","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2011.12.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2011.638999"},{"key":"e_1_2_6_6_1","first-page":"CD004661","article-title":"Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus","author":"Doyle LW","year":"2009","journal-title":"Cochrane database Syst Rev"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ae98c2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16239"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1471-0528.2006.01166.x","article-title":"The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre\u2010eclampsia. Outcome for women at 2 years","volume":"114","author":"Duley L","year":"2007","journal-title":"BJOG"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001195"},{"key":"e_1_2_6_12_1","unstructured":"HigginsJPT ThomasJ ChandlerJ CumpstonM LiT PageMJWV.Cochrane Handbook for Systematic Reviews of Interventions version 6.0.2019."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02782.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn188"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.10.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801187"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2669"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123544"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01162.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.11.048"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.05.011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059202"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78914-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013952"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2018-0174"},{"key":"e_1_2_6_27_1","first-page":"CD003898","article-title":"Inhaled magnesium sulfate in the treatment of acute asthma","volume":"11","author":"Knightly R","year":"2017","journal-title":"Cochrane database Syst Rev"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002398"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-91"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1279143"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.16238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.16238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T06:11:34Z","timestamp":1722665494000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.16238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,17]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/1471-0528.16238"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.16238","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,17]]},"assertion":[{"value":"2020-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}