{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:42:03Z","timestamp":1788586923241,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the effect of antenatal magnesium sulphate (MgSO<jats:sub>4<\/jats:sub>) on cerebral palsy (CP) in a manner that also provides adequate power for a linked trial sequential analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Double\u2010blind, randomised, placebo\u2010controlled, multi\u2010centre trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Fourteen Danish obstetric departments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In total, 560 pregnant women at risk for preterm delivery before 32\u00a0weeks of gestation were randomised from December 2011 to January 2018. Those women gave birth to 680 children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women were\u00a0randomised\u00a0to receive either a loading dose of 5 g MgSO<jats:sub>4<\/jats:sub> followed by 1 g\/hour or a placebo in identical volumes. The children were followed up at a corrected age of 18\u00a0months or older with a review of their medical charts and with the Ages and Stages Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>The primary outcome measure was moderate to severe CP. Secondary outcomes included mortality, neonatal morbidity, blindness and mild CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The crude rates of moderate to severe CP in the MgSO<jats:sub>4<\/jats:sub> group and the placebo group were 2.0% and 3.3%, respectively. The adjusted odds of moderate to severe CP were lower in the MgSO<jats:sub>4<\/jats:sub> group than in the placebo group (odds ratio 0.61; 95% CI 0.23\u20131.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antenatal MgSO<jats:sub>4<\/jats:sub> before 32\u00a0weeks of gestation decreases the likelihood of moderate to severe CP; these results are entirely consistent with other randomised evidence summarised in the linked trial sequential analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Antenatal magnesium sulphate may decrease the risk of moderate to severe cerebral palsy in children born before 32\u00a0weeks of gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16239","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T07:34:20Z","timestamp":1585726460000},"page":"1217-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Antenatal magnesium sulphate for the prevention of cerebral palsy in infants born preterm: a double\u2010blind, randomised, placebo\u2010controlled, multi\u2010centre trial"],"prefix":"10.1111","volume":"127","author":[{"given":"HT","family":"Wolf","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Brok","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen 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