{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:22:00Z","timestamp":1790284920823,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T00:00:00Z","timestamp":1589068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Isala Research foundation"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether laparoscopic sacrohysteropexy (LSH) is non\u2010inferior to vaginal sacrospinous hysteropexy (SSHP) in the surgical treatment of uterine prolapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multicentre randomised controlled, non\u2010blinded non\u2010inferiority trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Five non\u2010university teaching hospitals in the Netherlands, one university hospital in Belgium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>126 women with uterine prolapse stage 2 or higher undergoing surgery without previous pelvic floor surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomisation in a 1:1 ratio to LSH or SSHP, stratified per centre and severity of the uterine prolapse. The predefined inferiority margin was an increase in surgical failure rate of 10%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Primary outcome was surgical failure, defined as recurrence of uterine prolapse (POP\u2010Q\u00a0\u2265\u00a02) with bothersome bulging\/protrusion symptoms and\/or repeat surgery or pessary at 12\u00a0months postoperatively. Secondary outcomes were anatomical recurrence (any compartment), functional outcome and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Laparoscopic sacrohysteropexy was non\u2010inferior for surgical failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a01, 1.6%) compared with SSHP (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, 3.3%, difference \u22121.7%, 95% CI: \u22127.1 to 3.7) 12\u00a0months postoperatively. Overall, anatomical recurrences and quality of life did not differ. More bothersome symptoms of overactive bladder (OAB) and faecal incontinence were reported after LSH. Dyspareunia was more frequently reported after SSHP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laparoscopic sacrohysteropexy was non\u2010inferior to SSHP for surgical failure of the apical compartment at 12\u00a0months\u2019 follow up. Following LSH, bothersome OAB and faecal incontinence were more frequent, but dyspareunia was less frequent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Laparoscopic sacrohysteropexy and vaginal sacrospinous hysteropexy have equally good short\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16242","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T14:34:27Z","timestamp":1586356467000},"page":"1284-1293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hysteropexy in the treatment of uterine prolapse stage 2 or higher: laparoscopic sacrohysteropexy versus sacrospinous hysteropexy\u2014a multicentre randomised controlled trial (LAVA trial)"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-1077","authenticated-orcid":false,"given":"MN","family":"van 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