{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:10:14Z","timestamp":1777342214066,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the long\u2010term symptom alleviation and re\u2010intervention of high\u2010intensity focused ultrasound (HIFU) ablation and secondary myomectomy for women with recurrent symptomatic uterine fibroids following myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A general hospital in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>One hundred and eighty\u2010eight women with recurrent symptomatic uterine fibroids following myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women who underwent HIFU ablation (<jats:italic>n<\/jats:italic>\u00a0=\u00a0101) and secondary myomectomy (<jats:italic>n<\/jats:italic>\u00a0=\u00a087) at Chinese PLA General Hospital from January 2008 to December 2016 were analysed. Symptom relief and recurrence were evaluated using the transformed symptom severity scale (tSSS). The additional intervention and treatment\u2010related complications were also recorded and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Difference in symptom alleviation, recurrence, re\u2010intervention and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up time was comparable for the two groups (56 versus 60\u00a0months; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.88). Regarding tSSS, at 3\u00a0months there was improvement in all tSSS for both treatment groups. The time to re\u2010intervention was shorter in the myomectomy group. The cumulative risk for re\u2010intervention after HIFU ablation at 1 and 3\u00a0years was lower than that after secondary myomectomy (0% versus 4.8%, 3.2% versus 11.9%, respectively); however, no significant difference was observed at 5 and 8\u00a0years. There were fewer adverse events in the HIFU ablation group than the myomectomy group (59.4% versus 77%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010intensity focused ultrasound ablation of recurrent symptomatic uterine fibroids offers comparable long\u2010term alleviation of symptoms with longer time interval to re\u2010intervention and fewer adverse events compared with secondary myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>High\u2010intensity focused ultrasound ablation of recurrent uterine fibroids offered a longer time interval to re\u2010intervention and fewer adverse events compared with myomectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16262","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T06:31:37Z","timestamp":1586845897000},"page":"1422-1428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Comparison of high\u2010intensity focused ultrasound ablation and secondary myomectomy for recurrent symptomatic uterine fibroids following myomectomy: a retrospective study"],"prefix":"10.1111","volume":"127","author":[{"given":"X","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Chinese PLA General Hospital Medical School of Chinese PLA Beijing China"},{"name":"Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Chinese PLA General 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