{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:38:09Z","timestamp":1783384689458,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UM.BKP082\u20102016"],"award-info":[{"award-number":["UM.BKP082\u20102016"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate fasting for 12\u00a0hours compared with expedited oral feeding in hospitalised women with hyperemesis gravidarum (HG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University Hospital, Malaysia: April 2016\u2013April 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>One hundred and sixty women hospitalised for HG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Women were randomised upon admission to fasting for 12\u00a0hours or expedited oral feeding. Standard HG care was instituted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Primary outcome was satisfaction score with overall treatment at 24\u00a0hours (0\u201310 Visual Numerical Rating Scale VNRS), vomiting episodes within 24\u00a0hours and nausea VNRS score at enrolment, and at 8, 16 and 24\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Satisfaction score, median (interquartile range) 8 (5\u20139) versus 8 (7\u20139) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.08) and 24\u2010hour vomiting episodes were 1 (0\u20134) versus 1 (0\u20135) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.24) for 12\u2010hour fasting versus expedited feeding, respectively. Repeated measures analysis of variance of nausea scores over 24\u00a0hours showed no difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.11) between trial arms. Participants randomised to 12\u2010hour fasting compared with expedited feeding were less likely to prefer their feeding regimen in future hospitalisation (41% versus 65%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), to recommend to a friend (65% versus 84%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01; RR 0.8, 95% CI 0.6\u20130.9) and to adhere to protocol (85% versus 95%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04; RR 0.9, 95% CI 0.8\u20131.0). Symptoms profile, ketonuria status at 24\u00a0hours and length of hospital stay were not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Advisory of 12\u2010hour fasting compared with immediate oral feeding resulted in a non\u2010significant difference in satisfaction score but adherence to protocol and fidelity to and recommendation of immediate oral feeding to a friend were lower. The 24\u2010hour nausea scores and vomiting episodes were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Women hospitalised for hyperemesis gravidarum could feed as soon, as much and as often as can be tolerated compared with initial fasting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16290","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T05:27:25Z","timestamp":1588310845000},"page":"1430-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Twelve\u2010hour fasting compared with expedited oral intake in the initial inpatient management of hyperemesis gravidarum: a randomised trial"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-6581","authenticated-orcid":false,"given":"PC","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Abdussyukur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BK","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ST","family":"Win","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SZ","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02024-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.5641"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew128"},{"key":"e_1_2_6_5_1","volume-title":"The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum Green\u2010top Guidelines No. 69","author":"RCOG","year":"2016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328342d208"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000242"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00632.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181d99290"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16172"},{"key":"e_1_2_6_11_1","volume-title":"Postoperative Nausea","author":"Sizemore DC","year":"2019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001244"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90055-7"},{"issue":"8","key":"e_1_2_6_14_1","first-page":"CD001241","article-title":"Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants","author":"Oddie SJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"e_1_2_6_15_1","first-page":"CD001970","article-title":"Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants","author":"Morgan J","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.02.082"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9582"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4844-y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000375"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14211"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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