{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:51:54Z","timestamp":1792522314032,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a core outcome set for pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Consensus development study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>International.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Two hundred and eight\u2010one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Modified Delphi method and Modified Nominal Group Technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A long\u2010list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre\u2010eclampsia trials with those derived from thematic analysis of 30 in\u2010depth interviews of women with lived experience of pre\u2010eclampsia. Forty\u2010seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small\u2010for\u2010gestational\u2010age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The core outcome set for pre\u2010eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.]<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16319","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T18:11:06Z","timestamp":1589652666000},"page":"1516-1526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["A core outcome set for pre\u2010eclampsia research: an international consensus development study"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6127-9859","authenticated-orcid":false,"given":"JMN","family":"Duffy","sequence":"first","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford Oxford UK"},{"name":"Institute for Women's Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AE","family":"Cairns","sequence":"additional","affiliation":[{"name":"Institute for Women's Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-0259","authenticated-orcid":false,"given":"D","family":"Richards\u2010Doran","sequence":"additional","affiliation":[{"name":"Institute for Women's Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van 't Hooft","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gale","sequence":"additional","affiliation":[{"name":"Academic Neonatal Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine St George Hospital and University of New South Wales Kogarah NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LC","family":"Chappell","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health School of Life Course Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WA","family":"Grobman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Health Services Research Unit Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Karumanchi","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Khalil","sequence":"additional","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DN","family":"Lucas","sequence":"additional","affiliation":[{"name":"London North West University Healthcare NHS Trust Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LA","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health School of Life Course Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-550X","authenticated-orcid":false,"given":"BW","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash University Clayton Vic. 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