{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:37:28Z","timestamp":1792201048491,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the incidence of clinical, ultrasonographic and biochemical findings related to pre\u2010eclampsia (PE) in pregnancies with COVID\u201019, and to assess their accuracy to differentiate between PE and the PE\u2010like features associated with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective, observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Singleton pregnancies with COVID\u201019 at &gt;20<jats:sup>+0<\/jats:sup>\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two consecutive pregnancies were recruited and classified into two groups: severe and non\u2010severe COVID\u201019, according to the occurrence of severe pneumonia. Uterine artery pulsatility index (UtAPI) and angiogenic factors (soluble fms\u2010like tyrosine kinase\u20101\/placental growth factor [sFlt\u20101\/PlGF]) were assessed in women with suspected PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Incidence of signs and symptoms related to PE, such as hypertension, proteinuria, thrombocytopenia, elevated liver enzymes, abnormal UtAPI and increased sFlt\u20101\/PlGF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four cases were classified as non\u2010severe and 8 as severe COVID\u201019. Five (11.9%) women presented signs and symptoms of PE, all five being among the severe COVID\u201019 cases (62.5%). However, abnormal sFlt\u20101\/PlGF and UtAPI could only be demonstrated in one case. One case remained pregnant after recovery from severe pneumonia and had a spontaneous resolution of the PE\u2010like syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregnant women with severe COVID\u201019 can develop a PE\u2010like syndrome that might be distinguished from actual PE by sFlt\u20101\/PlGF, LDH and UtAPI assessment. Healthcare providers should be aware of its existence and monitor pregnancies with suspected pre\u2010eclampsia with caution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>This study shows that a pre\u2010eclampsia\u2010like syndrome could be present in some pregnancies with severe COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16339","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T20:31:16Z","timestamp":1591043476000},"page":"1374-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":278,"title":["Pre\u2010eclampsia\u2010like syndrome induced by severe COVID\u201019: a prospective observational study"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-3833","authenticated-orcid":false,"given":"M","family":"Mendoza","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-7795","authenticated-orcid":false,"given":"I","family":"Garcia\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-6383","authenticated-orcid":false,"given":"N","family":"Maiz","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-5677","authenticated-orcid":false,"given":"C","family":"Rodo","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-1626","authenticated-orcid":false,"given":"P","family":"Garcia\u2010Manau","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Serrano","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RM","family":"Lopez\u2010Martinez","sequence":"additional","affiliation":[{"name":"Biochemistry Department Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-6508","authenticated-orcid":false,"given":"J","family":"Balcells","sequence":"additional","affiliation":[{"name":"Paediatric Critical Care Department Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-344X","authenticated-orcid":false,"given":"N","family":"Fernandez\u2010Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Infectous Diseases Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Red 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