{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:04:41Z","timestamp":1792062281124,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy of hormonal regimens for the prevention of endometrioma recurrence in women who have undergone conservative surgery is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of different hormonal regimens in this context and to rank them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search strategy<\/jats:title>\n                    <jats:p>MEDLINE and Scopus databases were searched through January 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection criteria<\/jats:title>\n                    <jats:p>Randomised controlled trials (RCTs) or cohorts, comparing the effect of any pair of interventions (i.e. cyclic oral contraceptives [OC], continuous OC, gonadotropin\u2010releasing hormone agonist [GnRHa], dienogest [DNG], levonorgestrel\u2010releasing intrauterine system [LNG\u2010IUS] and expectant management) on endometrioma recurrence were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and analysis<\/jats:title>\n                    <jats:p>Data were independently extracted by two reviewers. Relative treatment effects were estimated using network meta\u2010analysis (NMA) and ranked in descending order.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>Six RCTs (675 patients) and 16 cohorts (3089 patients) were included. NMA of the RCTs involving expectant management, cyclic OC, continuous OC, GnRHa and GnRHa\u00a0+\u00a0LNG\u2010IUS, showed that all hormonal regimens had a nonsignificant lower risk of endometrioma recurrence compared with expectant management. NMA of the cohorts involving expectant, cyclic OC, continuous OC, GnRHa, DNG, LNG\u2010IUS, GnRHa\u00a0+\u00a0OC, and GnRHa\u00a0+\u00a0LNG\u2010IUS indicated that LNG\u2010IUS, DNG, continuous OC, GnRHa\u00a0+\u00a0OC and cyclic OC had a significantly lower risk of endometrioma recurrence than expectant management. LNG\u2010IUS was ranked highest, followed by DNG and GnRHa\u00a0+\u00a0LNG\u2010IUS. Long\u2010term use of hormonal treatment either OC or progestin had a significantly lower risk of endometrioma recurrence than expectant treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the NMA of RCTs, there was no evidence supporting hormonal treatment for postoperative prevention of endometrioma recurrence. This was at odds with the cohort evidence, which found the protective effect of OC and progestin regimens, especially long\u2010term treatment. Large\u2010scale RCTs of these agents are still required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Hormonal regimens given as long\u2010term treatment tend to reduce risk of endometrioma recurrence after conservative surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16366","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T10:25:57Z","timestamp":1592562357000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Postoperative hormonal treatment for prevention of endometrioma recurrence after ovarian cystectomy: a systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1434-4627","authenticated-orcid":false,"given":"R","family":"Wattanayingcharoenchai","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-6116","authenticated-orcid":false,"given":"S","family":"Rattanasiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Charakorn","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Attia","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology and Biostatistics School of Medicine and Public Health Faculty of Health and Medicine University of Newcastle New Lambton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Thakkinstian","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000265215.87717.8b"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1752"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.03.069"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.255"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.08.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340903214973"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del125"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.04.018"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.08.026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000084247.09900.4f"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34589-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det457"},{"key":"e_1_2_6_14_1","unstructured":"National Institute for Health and Care Excellence.Endometriosis: diagnosis and management. 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