{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:43Z","timestamp":1791229483773,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess in women with early\u2010onset severe pre\u2010eclampsia whether longitudinal changes in angiogenic factors improve the prediction of adverse outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Maternity units in two Spanish hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with diagnosis of early\u2010onset severe pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Levels of placental growth factor (PlGF), soluble fms\u2010like tyrosine kinase (sFlt\u2010) and sFlt\u20101\/PlGF ratio were measured at admission and before delivery, and average daily change calculated. The association of longitudinal changes of angiogenic factors with the time interval to delivery and with complications was evaluated by logistic and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Interval to delivery and composite of adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 63 women, of which 26 (41.3%) had a complication. Longitudinal changes of sFlt\u20101 were more pronounced in complicated pregnancies (median: 1047 versus 342\u00a0pg\/ml\/day; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). On the multivariate analysis, the clinical risk score and sFlt\u20101 at admission explained 6.2% of the uncertainty for complication; the addition of sFlt\u20101 longitudinal changes improved this to 25.3% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). The median time from admission to delivery was 4\u00a0days (95% CI 1.6\u20136.04) in those in the highest quartile of sFlt\u20101 longitudinal changes versus 16\u00a0days (95% CI 12.4\u201319.6) in the remaining women (Log\u2010rank test <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal changes in sFlt\u20101 maternal levels from admission for confirmed early\u2010onset severe pre\u2010eclampsia add to baseline characteristics in the prediction of adverse outcome and interval to delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>In early\u2010onset severe pre\u2010eclampsia, longitudinal changes in sFlt\u20101 levels improve the prediction of complications and interval to delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16383","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T21:20:49Z","timestamp":1593292849000},"page":"158-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Added prognostic value of longitudinal changes of angiogenic factors in early\u2010onset severe pre\u2010eclampsia: a prospective cohort study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-4054","authenticated-orcid":false,"given":"A","family":"Peguero","sequence":"first","affiliation":[{"name":"BCNatal, Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia Fetal i+D Fetal Medicine Research Center Barcelona 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Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia Fetal i+D Fetal Medicine Research Center Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"BCNatal, Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia Fetal i+D Fetal Medicine Research Center Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Youssef","sequence":"additional","affiliation":[{"name":"BCNatal, Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia Fetal i+D Fetal Medicine Research Center Barcelona 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