{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:29:56Z","timestamp":1794083396465,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["210182\/Z\/18\/Z"],"award-info":[{"award-number":["210182\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesised that a multi\u2010compartment magnetic resonance imaging (MRI) technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early\u2010onset fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>London, UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with uncomplicated pregnancies (estimated fetal weight [EFW] &gt;10th centile for gestational age [GA] and normal maternal and fetal Doppler ultrasound, <jats:italic>n<\/jats:italic>\u00a0=\u00a012) or early\u2010onset FGR (EFW &lt;3rd centile with or without abnormal Doppler ultrasound &lt;32\u00a0weeks GA, <jats:italic>n<\/jats:italic>\u00a0=\u00a012) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All women underwent MRI examination. Using a multi\u2010compartment MRI technique, we quantified fetal and maternal blood volume and feto\u2010placental blood oxygenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Disease severity was stratified according to Doppler pulsatility index and the relationship to the MRI parameters was investigated, including the influence of GA at scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FGR group (mean GA 27<jats:sup>+5<\/jats:sup>\u00a0weeks, range 24<jats:sup>+2<\/jats:sup> to 33<jats:sup>+6<\/jats:sup>\u00a0weeks) had a significantly lower EFW compared with the control group (mean GA 29<jats:sup>+1<\/jats:sup>\u00a0weeks; \u2212705\u00a0g, 95% CI \u2212353 to \u22121057\u00a0g). MRI\u2010derived feto\u2010placental oxygen saturation was higher in controls compared with FGR (75\u00a0\u00b1\u00a09.6% versus 56\u00a0\u00b1\u00a016.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02, 95% CI 7.8\u201330.3%). Feto\u2010placental oxygen saturation estimation correlated strongly with GA at scan in controls (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using a novel multimodal MRI protocol we demonstrated reduced feto\u2010placental blood oxygen saturation in pregnancies complicated by early\u2010onset FGR. The degree of abnormality correlated with disease severity defined by ultrasound Doppler findings. Gestational age\u2010dependent changes in oxygen saturation were also present in normal pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>MRI reveals differences in feto\u2010placental oxygen saturation between normal and FGR pregnancy that is associated with disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16387","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T21:08:16Z","timestamp":1593551296000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early\u2010onset fetal growth restriction"],"prefix":"10.1111","volume":"128","author":[{"given":"R","family":"Aughwane","sequence":"first","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London London 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