{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:18Z","timestamp":1787013678170,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1121844"],"award-info":[{"award-number":["APP1121844"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1027196"],"award-info":[{"award-number":["APP1027196"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between age at menarche and risk of vasomotor menopausal symptoms (VMS) and whether midlife body mass index (BMI) modified the association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A pooled analysis of six cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The International collaboration on the Life course Approach to reproductive health and Chronic disease Events (InterLACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>18\u00a0555 women from the UK, USA and Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      VMS frequency data (never, rarely, sometimes and often) were harmonised from two studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013\u00a0602); severity data (never, mild, moderate and severe) from the other four studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04953). Multinominal logistic regression models were used to estimate relative risk ratios (RRRs) and 95%\u00a0CIs adjusted for confounders and incorporated study as random effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Hot flushes and night sweats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Frequency data showed that early menarche \u226411\u00a0years was associated with an increased risk of \u2018often\u2019 hot flushes (RRR 1.48, 95% CI 1.24\u20131.76) and night sweats (RRR 1.59, 95% CI 1.49\u20131.70) compared with menarche at \u226514\u00a0years. Severity data showed similar results, but appeared less conclusive, with RRRs of 1.16 (95% CI 0.94\u20131.42) and 1.27 (95% CI 1.01\u20131.58) for \u2018severe\u2019 hot flushes and night sweats, respectively. BMI significantly modified the association as the risk associated with early menarche and \u2018often\u2019 VMS was stronger among women who were overweight or obese than those of normal weight, while this gradient across BMI categories was not as strong with the risk of \u2018severe\u2019 VMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early age at menarche is a risk factor for VMS, particularly for frequent VMS, but midlife BMI may play an important role in modifying this risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Overweight and obesity exacerbate the risk of vasomotor symptoms associated with early menarche.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.16393","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T20:03:10Z","timestamp":1595361790000},"page":"603-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Age at menarche and risk of vasomotor menopausal symptoms: a pooled analysis of six studies"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-5942","authenticated-orcid":false,"given":"H\u2010F","family":"Chung","sequence":"first","affiliation":[{"name":"School of Public Health The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AJ","family":"Dobson","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kuh","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit for Lifelong Health and Ageing at UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EB","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SL","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NE","family":"Avis","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ES","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Family and Child Nursing School of Nursing University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NF","family":"Woods","sequence":"additional","affiliation":[{"name":"Biobehavioral Nursing and Health Systems School of Nursing University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DJ","family":"Anderson","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland Griffith University Gold Coast Queensland Australia"},{"name":"Faculty of Health University of Technology Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GD","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.02.004"},{"key":"e_1_2_6_4_1","first-page":"679","article-title":"Early menarche, nulliparity and the risk for premature and early natural menopause","volume":"32","author":"Mishra GD","year":"2017","journal-title":"Hum Reprod"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001058"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2011.05.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2005.066936"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000434"},{"key":"e_1_2_6_9_1","first-page":"192","article-title":"Factors affecting the age in normal menopause and frequency of menopausal symptoms in Northern Iran","volume":"13","author":"Delavar MA","year":"2011","journal-title":"Iran Red Crescent Med J"},{"key":"e_1_2_6_10_1","first-page":"29","article-title":"Risk factors for menopausal hot flashes","volume":"84","author":"Schwingl PJ","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e3182844a7c"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.1998.7.1149"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6300(1996)8:6<761::AID-AJHB8>3.0.CO;2-W"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2011.09.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.2999"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13336"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.07.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70425-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157417"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001033"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001283"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.177"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.07.021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.12.011"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781412984829"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000723"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718000168"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.043182"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11208"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.2.405"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27567"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2011.608596"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000884"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000546"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.02064.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/gme.0b013e31804d2406","article-title":"Association of estrogen\u2010related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition","volume":"15","author":"Mitchell ES","year":"2008","journal-title":"Menopause"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000227058.70903.9f"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.16393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.16393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:17:50Z","timestamp":1693189070000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.16393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/1471-0528.16393"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.16393","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"2020-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}