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We argue that methylation assays can be used: 1. for primary triage of hrHPV\u2010positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high\u2010risk HPV infection.<\/jats:p>\n                  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