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Baseline characteristics were described using descriptive statistics. Logistic\/linear regression models analysed the impact of variables on RRESDO acceptability and health outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes<\/jats:title><jats:p>RRESDO acceptability, menopausal sequelae, satisfaction\/regret.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 346 of 683 participants underwent risk\u2010reducing salpingo\u2010oophorectomy (RRSO). Of premenopausal women who had not undergone RRSO, 69.1% (181\/262) found it acceptable to participate in a research study offering RRESDO. Premenopausal women concerned about sexual dysfunction were more likely to find RRESDO acceptable (odds ratio [OR]\u00a0=\u00a02.9, 95% CI\u00a01.2\u20137.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025). Women experiencing sexual dysfunction after premenopausal RRSO were more likely to find RRESDO acceptable in retrospect (OR\u00a0=\u00a05.3, 95% CI 1.2\u201327.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.031). In all, 88.8% (143\/161) premenopausal and 95.2% (80\/84) postmenopausal women who underwent RRSO, respectively, were satisfied with their decision, whereas 9.4% (15\/160) premenopausal and 1.2% (1\/81) postmenopausal women who underwent RRSO regretted their decision. HRT uptake in premenopausal individuals without breast cancer (BC) was 74.1% (80\/108). HRT use did not significantly affect satisfaction\/regret levels but did reduce symptoms of vaginal dryness (OR\u00a0=\u00a00.4, 95% CI 0.2\u20130.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data show high RRESDO acceptability, particularly in women concerned about sexual dysfunction. Although RRSO satisfaction remains high, regret rates are much higher for premenopausal women than for postmenopausal women. HRT use following premenopausal RRSO does not increase satisfaction but does reduce vaginal dryness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>RRESDO has high acceptability among premenopausal women at increased ovarian cancer risk, particularly those concerned about sexual dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16424","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T07:14:41Z","timestamp":1598598881000},"page":"714-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Attitudes towards risk\u2010reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-6883","authenticated-orcid":false,"given":"F","family":"Gaba","sequence":"first","affiliation":[{"name":"Wolfson Institute of 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