{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:11:53Z","timestamp":1778037113673,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study using administrative health data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>General population of Ferrara Province, Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Female residents born in 1986\u20131993 and participating in the organized cervical screening programme in 2011\u20132018, who were eligible for HPV vaccination in catch\u2010up cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Logistic regression to evaluate the potential association between abnormal cervical cytology and one, two, three or at least one dose of HPV vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Cervical abnormalities, as predicted by low\u2010grade or high\u2010grade cytology, by number of vaccine doses, stratified by age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample consisted of 7785 women (mean age 27.5\u00a0years, SD 2.3). Overall, 391 (5.0%) were vaccinated with \u22651 dose and 893 (11.5%) had abnormal cytology. Women receiving at least one vaccine dose were significantly less likely to have an abnormal cytology (adjusted odds ratio 0.52; 95% confidence interval 0.34\u20130.79). Similar results were observed for women receiving a single dose, for both bivalent and quadrivalent vaccines, and applying buffer periods (excluding cytological outcomes within 1 month, 6 months and 1 year of the first dose).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the context of an organised cervical screening programme in Italy, catch\u2010up HPV vaccination almost halved the risk of cytological abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Among Ferrara women, vaccination against human papillomavirus halved the risk of screening cervical abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16429","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T06:56:02Z","timestamp":1597128962000},"page":"532-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Human papillomavirus vaccine 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