{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:36:51Z","timestamp":1769114211728,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["765274"],"award-info":[{"award-number":["765274"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between deferred delivery in early\u2010onset pre\u2010eclampsia and offspring outcome and maternal cardiovascular, renal and metabolic function in the postpartum period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Nulliparous women diagnosed with pre\u2010eclampsia before 34\u00a0weeks\u2019 gestation who participated in a routine postpartum cardiovascular risk assessment programme. Women with hypertension, diabetes mellitus or renal disease prior to pregnancy were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Regression analyses were performed to assess the association between pregnancy prolongation and outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Offspring outcome and prevalence of deviant maternal cardiovascular, renal and metabolic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 564 women with a median pregnancy prolongation of 10\u00a0days (interquartile range [IQR] 4\u201318) who were assessed at on average 8\u00a0months (IQR 6\u201312) postpartum. Pregnancy prolongation after diagnosis resulted in a decrease in infant mortality (adjusted odd ratio [aOR] 0.907, 95% CI 0.852\u20130.965 per day prolongation). This improvement in offspring outcome was associated with an elevated risk of moderately increased albuminuria (aOR 1.025, 95% CI 1.006\u20131.045 per day prolongation), but not with aberrant cardiac geometry, cardiac systolic or diastolic dysfunction, persistent hypertension or metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnancy prolongation in early\u2010onset pre\u2010eclampsia is associated with improved offspring outcome and survival. These effects do not appear to be deleterious to short\u2010term maternal cardiovascular and metabolic function but are associated with a modest increase in risk of residual albuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Pregnancy prolongation in pre\u2010eclampsia has only a limited effect on postpartum maternal cardiovascular function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16435","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T06:44:55Z","timestamp":1596005095000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of pregnancy prolongation in early\u2010onset pre\u2010eclampsia on postpartum maternal cardiovascular, renal and metabolic function in primiparous women: an observational study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-8528","authenticated-orcid":false,"given":"EG","family":"Mulder","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ghossein\u2010Doha","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JRW","family":"Crutsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SMJ","family":"Van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Thilaganathan","sequence":"additional","affiliation":[{"name":"St George's University of London, Molecular and Clinical Sciences Research Institute St\u00a0George's University Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEA","family":"Spaanderman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39366.416817.BE"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.03.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199912000-00014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176537"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003497"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.045"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943407"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2019.62.4.233"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60741-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4281-9"},{"key":"e_1_2_6_12_1","unstructured":"National Institute for Health and Clinical Excellence Hypertension in pregnancy: the management of hypertensive disorders of pregnancy NICE clinical guideline 107 August 2010. 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