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Multivariable logistic regression was used to test the association of each continuous scaled genetic instrument with pre\u2010eclampsia. Odds of pre\u2010eclampsia were compared across quartiles of the genetic instrument and evaluated for significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Genetic predisposition to medical conditions and relationship with pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increasing burden of risk alleles for elevated diastolic blood pressure (DBP) and increased body mass index (BMI) were associated with an increased risk of pre\u2010eclampsia (DBP, overall OR 1.11, 95%\u00a0CI 1.01\u20131.21, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025; BMI, OR 1.10, 95%\u00a0CI 1.00\u20131.20, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.042), whereas alleles associated with elevated alkaline phosphatase (ALP) were protective (OR 0.89, 95%\u00a0CI 0.82\u20130.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), driven primarily by pleiotropic effects of variants in the <jats:italic>FADS<\/jats:italic> gene region. The effect of DBP genetic loci was even greater in early\u2010onset pre\u2010eclampsia cases (at &lt;34\u00a0weeks of gestation, OR 1.30, 95%\u00a0CI 1.08\u20131.56, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). For other traits, there was no evidence of an association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the underlying genetic architecture of pre\u2010eclampsia may be shared with other disorders, specifically hypertension and obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A genetic predisposition to increased diastolic blood pressure and obesity increases the risk of pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16441","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T15:30:31Z","timestamp":1596382231000},"page":"55-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Risk of pre\u2010eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case\u2013control 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