{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:55:48Z","timestamp":1782755748694,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a dichorionic twin pregnancy specific reference range for placental growth factor (PlGF), and to compare gestation\u2010specific placental growth factor levels in twin pregnancies later complicated by pre\u2010eclampsia, hypertensive disorder of pregnancy or fetal growth restriction with control pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single large tertiary maternity unit in Ireland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or Sample<\/jats:title><jats:p>Women with a twin pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consenting pregnant women, across a variety of gestations, had a single blood sample taken at one time\u2010point only during their pregnancy. The plasma was initially biobanked and PlGF was measured later in batches using the point of care Triage<jats:sup>\u00ae<\/jats:sup> PlGF test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Development of pre\u2010eclampsia, hypertensive disorder of pregnancy or fetal growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Placental growth factor levels in uncomplicated dichorionic twin pregnancies were significantly lower in the women who later developed pre\u2010eclampsia than in the controls at all gestational intervals. In those that later developed any hypertensive disorder of pregnancy, median PlGF was lower only in those recruited before 24\u00a0weeks of gestation, whereas in infants with a customised birthweight below the third centile, PlGF was lower only in those sampled after 24\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Placental growth factor levels in twin pregnancy differ significantly between those women with a pregnancy that will later be complicated by pre\u2010eclampsia and those that will not. This difference is present many weeks before clinical signs or symptoms of disease are present. Using cross\u2010sectional values from uncomplicated twin pregnancies, we have developed a dichorionic twin pregnancy specific reference range for PlGF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable Abstract<\/jats:title><jats:p>Placental growth factor levels in twin pregnancy differ significantly between women that will later develop pre\u2010eclampsia and those that will not.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16518","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T20:41:28Z","timestamp":1600461688000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A prospective study of placental growth factor in twin pregnancy and development of a dichorionic twin pregnancy specific reference range"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-3661","authenticated-orcid":false,"given":"D","family":"Hayes\u2010Ryan","sequence":"first","affiliation":[{"name":"The Irish Centre for Maternal and Child Health Research (INFANT) Cork Ireland"},{"name":"Cork University Maternity Hospital (CUMH) Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Meaney","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology Centre University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AP","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"School of Public Health University College Cork Cork Ireland"},{"name":"Department of Statistics University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"O\u2019Mahony","sequence":"additional","affiliation":[{"name":"The Irish Centre for Maternal and Child Health Research (INFANT) Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Normile","sequence":"additional","affiliation":[{"name":"The Irish Centre for Maternal and Child Health Research (INFANT) Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LC","family":"Kenny","sequence":"additional","affiliation":[{"name":"Faculty of Health &amp; Life Sciences University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"The Irish Centre for Maternal and Child Health Research (INFANT) Cork Ireland"},{"name":"Cork University Maternity Hospital (CUMH) Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70350-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-005-0089-8"},{"key":"e_1_2_6_10_1","unstructured":"Central Statistics Office 2016[Available from:www.cso.ie]."},{"key":"e_1_2_6_11_1","first-page":"1","article-title":"Trends in twin and triplet births: 1980\u201397","volume":"47","author":"Martin JA","year":"1999","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_12_1","unstructured":"Office for National Statistics. Births: maternities with multiple births: rates per 1 m age of mother 1938e2004 all maternities. London: ONS; 2006.; 2017."},{"key":"e_1_2_6_13_1","first-page":"70","article-title":"Trends in the obstetric features and management of twin pregnancies","volume":"103","author":"Smith KE","year":"2010","journal-title":"Ir Med J"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119388"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031244"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021942"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.111"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9267"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122969"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_6_22_1","unstructured":"NICE.PlGF\u2010based testing to help diagnose suspected pre\u2010eclampsia (Triage PlGF test Elecsys immunoassay sFlt\u20101\/PlGF ratio DELFIA Xpress PlGF 1\u20132\u20103 test and BRAHMS sFlt\u20101 Kryptor\/BRAHMS PlGF plus Kryptor PE ra 2016 [Diagnostics guidance [DG23]Published date: May 2016:[Available from:https:\/\/www.nice.org.uk\/guidance\/dg23\/chapter\/1\u2010Recommendations]."},{"key":"e_1_2_6_23_1","unstructured":"Ireland P.PARROT Ireland 1997[Available from:https:\/\/parrotireland.medscinet.com\/]."},{"issue":"74","key":"e_1_2_6_24_1","first-page":"983","article-title":"Randomized interventional study on prediction of preeclampsia\/eclampsia in women with suspected preeclampsia: INSPIRE","volume":"2019","author":"Cerdeira AS","year":"1979","journal-title":"Hypertension"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","unstructured":"DuhigKE MyersJ SeedPT SparkesJ LoweJ HunterRM et al.Placental growth factor testing to assess women with suspected pre\u2010eclampsia: a multicentre pragmatic stepped\u2010wedge cluster\u2010randomised controlled trial. Lancet (London England).2019.","DOI":"10.1016\/S0140-6736(18)33212-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.845156"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1042"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.10.783"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.08.042"},{"key":"e_1_2_6_30_1","first-page":"607","article-title":"Risks for preeclampsia and small for gestational age: predictive values of placental growth factor, soluble fms\u2010like tyrosine kinase\u20101, and inhibin a in singleton and multiple\u2010gestation pregnancies","volume":"30","author":"Boucoiran I","year":"2013","journal-title":"Am J Perinatol"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.02.016"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.09.022"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2012.01507.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.11.035"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03578"},{"key":"e_1_2_6_36_1","unstructured":"NICE.Hypertension in Pregnancy 2010[Available from:https:\/\/www.nice.org.uk\/guidance\/cg107]."},{"key":"e_1_2_6_37_1","unstructured":"Weight GRO. [Available from:https:\/\/www.gestation.net\/cc\/about.htm]."},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.964"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2011.08.117"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2013.01.004"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der394"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.195065"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14760"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.12.176"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19069"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14825"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13410"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01343.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-016-0119-1"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13006.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5662"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002284"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19051"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6813"},{"key":"e_1_2_6_55_1","unstructured":"Alere.2013[Available from:https:\/\/www.quidel.com\/immunoassays\/triage\u2010test\u2010kits\/triage\u2010plgf\u2010test]."},{"key":"e_1_2_6_56_1","unstructured":"R & D.2016[Available from:https:\/\/www.rndsystems.com\/products\/human\u2010plgf\u2010quantikine\u2010elisa\u2010kit_dpg00]."},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414838"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003215"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.03.014"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12831"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.03.010"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.16518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:20:18Z","timestamp":1693563618000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.16518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/1471-0528.16518"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.16518","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"2020-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}