{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:30:19Z","timestamp":1777962619772,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001877","name":"Sterling-Turner Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015158","name":"Fondren Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify predictors for intact motor function (MF) at birth and at 12\u00a0months of life in babies with prenatally versus postnatally repaired open spina bifida (OSB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Texas Children's Hospital, 2011\u20132018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients who underwent either prenatal or postnatal OSB repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prenatal MF of the lower extremities was evaluated by ultrasound following a metameric distribution at the time of diagnosis (US1), 6\u00a0weeks postoperatively (or 6\u00a0weeks after initial evaluation in postnatally repaired cases) (US2) and at the last ultrasound before delivery (US3). At birth and at 12\u00a0months, MF was assessed clinically. Intact MF (S1) was defined as the observation of plantar flexion of the ankle. Results from logistic regression analysis are expressed as odds ratios (95% confidence intervals, <jats:italic>P<\/jats:italic> values).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 127 patients were included: 93 with prenatal repair (51 fetoscopic; 42 open hysterotomy repair) and 34 with postnatal repair. In the prenatal repair group, predictors for intact MF at birth and at 12\u00a0months included: absence of clubfeet (OR\u00a011.3, 95%\u00a0CI 3.2\u201339.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR\u00a010.8 95%\u00a0CI 2.4\u201347.6, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01); intact MF at US1 (OR\u00a019.7, 95%\u00a0CI 5.0\u201376.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR\u00a08.7, 95%\u00a0CI 2.0\u201338.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01); intact MF at US2 (OR\u00a022, 95%\u00a0CI 6.5\u201374.2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR\u00a013.5, 95%\u00a03.0\u201361.4, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01); intact MF at US3 (OR\u00a013.7, 95%\u00a0CI 3.4\u201355.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR\u00a012.6, 95%\u00a0CI 2.5\u201364.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01); and having a flat lesion (OR\u00a011.2, 95%\u00a0CI 2.4\u201351.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR\u00a04.1, 95%\u00a0CI 1.1\u201316.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). In the postnatal repair group, the only predictor of intact MF at 12\u00a0months was having intact MF at birth (OR\u00a015.2, 95%\u00a0CI 2.0\u2013113.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The detection of intact MF in\u00a0utero from mid\u2010gestation to delivery predicts intact MF at birth and at 12\u00a0months in babies who undergo prenatal OSB repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Detection of intact motor function in\u00a0utero predicts intact motor function at birth and at 1\u00a0year in fetuses who undergo prenatal OSB repair.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16538","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T16:21:19Z","timestamp":1601050879000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prenatal predictors of motor function in children with open spina bifida: a retrospective cohort study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-2054","authenticated-orcid":false,"given":"R","family":"Corroenne","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Yepez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pyarali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RM","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WE","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HA","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AR","family":"Mehollin\u2010Ray","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"},{"name":"Department of Radiology Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AA","family":"Shamshirsaz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-7965","authenticated-orcid":false,"given":"AA","family":"Nassr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MA","family":"Belfort","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MS","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1","article-title":"Updated estimates of neural tube defects prevented by mandatory folic Acid fortification \u2010 United States, 1995\u20132011","volume":"64","author":"Williams J","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617716000680"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-012-1761-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0792-3"},{"key":"e_1_2_11_6_1","first-page":"9","article-title":"Chronic herniation of the hindbrain","volume":"63","author":"Williams B","year":"1981","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2004.16.2.6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.09.020"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1996.tb12137.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264297"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.1.1523291"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6423"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(97)00090-X"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15732"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000404"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1992.tb11416.x"},{"key":"e_1_2_11_18_1","unstructured":"ClinicalTrials.gov;BelfortMA.Identifier NCT02230072; Fetoscopic Meningomyelocele Repair Study (fMMC).2014[https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT02230072]."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001941"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002577"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b48ef5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.PEDS17584"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.001"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.094"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117676"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199414060-00005"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91022-6"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6423"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.1.1523291"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.3.PEDS13597"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.05.002"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4807-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.20088"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000325"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3171\/2008.12.PEDS0874"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.2.PEDS08339"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.16538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.16538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:20:42Z","timestamp":1693563642000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.16538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/1471-0528.16538"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.16538","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"assertion":[{"value":"2020-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}