{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:25:38Z","timestamp":1777350338094,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) is present in the vaginal secretions of both reproductive\u2010aged and postmenopausal women during acute SARS\u2010CoV\u20102 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A single tertiary, university\u2010affiliated medical centre in Israel. Time period, 1 June 2020 through to 31 July 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women who were hospitalised in a single tertiary medical centre, who were diagnosed with acute SARS\u2010CoV\u20102 infection by a nasopharyngeal RT\u2010PCR test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women were diagnosed with acute SARS\u2010CoV\u20102 infection by a nasopharyngeal RT\u2010PCR test. Vaginal RT\u2010PCR swabs were obtained from all study participants after a proper cleansing of the perineum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Detection of SARS\u2010CoV\u20102 in vaginal RT\u2010PCR swabs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vaginal and nasopharyngeal swabs were obtained from 35 women, aged 21\u201393\u00a0years. Twenty\u2010one women (60%) were in their reproductive years, of whom, five were in their third trimester of pregnancy. Most of the participants (57%) were healthy without any underlying medical conditions. Of the 35 patients sampled, 2 (5.7%) had a positive vaginal RT\u2010PCR for SARS\u2010CoV\u20102, one was premenopausal and the other was a postmenopausal woman. Both women had mild disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings contradict most previous reports, which did not detect the presence of viral colonisation in the vagina. Although passage through the birth canal exposes neonates to the vaginal polymicrobial flora, an acquisition of pathogens does not necessarily mandate neonatal infection or clinical disease. Nevertheless, when delivering the infant of a woman with acute SARS\u2010CoV\u20102 infection, a clinician should consider the possibility of vaginal colonisation, even if it is uncommon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>When delivering the infant of a woman with acute SARS\u2010CoV\u20102 infection, a clinician should consider the possibility of vaginal colonisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16556","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T01:43:44Z","timestamp":1601948624000},"page":"97-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Detection of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) in vaginal swabs of women with acute SARS\u2010CoV\u20102 infection: a prospective study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-8932","authenticated-orcid":false,"given":"A","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lis Maternity Hospital Sourasky Medical Centre Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Yogev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lis Maternity Hospital Sourasky Medical Centre Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Zilberman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lis Maternity Hospital Sourasky Medical Centre Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Alpern","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lis Maternity Hospital Sourasky Medical Centre Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Many","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lis Maternity Hospital Sourasky Medical Centre Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Yousovich","sequence":"additional","affiliation":[{"name":"Maccabi Healthcare Services Herzliya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gamzu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Lis 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