{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T04:42:58Z","timestamp":1776660178229,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1R21TW010536\u201001"],"award-info":[{"award-number":["1R21TW010536\u201001"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate pregnancy and neonatal outcomes, disease severity, and mother\u2010to\u2010child transmission of pregnant women with Chikungunya infection (CHIKV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Grenada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This descriptive study investigated 731 mother\u2010infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour\/cervical incompetence, cesarean delivery for fetal distress\/abruption\/placental abnormality or delivery for fetal distress) and composite neonatal morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 416 mother\u2010infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (\u03bc\u00a0=\u00a0898\u00a0days, \u03c3\u00a0=\u00a0277\u00a0days) compared with infections outside of pregnancy (\u03bc\u00a0=\u00a01064\u00a0days, \u03c3\u00a0=\u00a0244\u00a0days) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Rates of pregnancy complications (RR\u00a0=\u00a00.76, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.599), intrapartum complications (RR\u00a0=\u00a01.50, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.633), and neonatal outcomes were otherwise similar. Possible mother\u2010to\u2010child transmission occurred in two (1.3%) mother\u2010infant pairs and two of eight intrapartum infections (25%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CHIKV infection during pregnancy may be protective against long\u2010term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother\u2010to\u2010child transmission of CHIKV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16562","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T11:46:15Z","timestamp":1602416775000},"page":"1077-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chikungunya infection in pregnancy \u2013 reassuring maternal and perinatal outcomes: a retrospective observational study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-7678","authenticated-orcid":false,"given":"ME","family":"Foeller","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Stanford University Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-0400","authenticated-orcid":false,"given":"C","family":"Nosrat","sequence":"additional","affiliation":[{"name":"Program in Human Biology Stanford University Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-8876","authenticated-orcid":false,"given":"A","family":"Krystosik","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Department of Pediatrics Stanford University, School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Noel","sequence":"additional","affiliation":[{"name":"Windward Islands Research and Education Foundation True Blue Grenada"},{"name":"St. George's University St. Georges Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-5919","authenticated-orcid":false,"given":"P","family":"G\u00e9rardin","sequence":"additional","affiliation":[{"name":"INSERM CIC1410 Centre Hospitalier Universitaire de la R\u00e9union Saint Pierre R\u00e9union"},{"name":"Unit\u00e9 Mixte 134 PIMIT (INSERM 1187, CNRS 9192, IRD 249, Universit\u00e9 de La R\u00e9union) Sainte Clotilde R\u00e9union"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Cudjoe","sequence":"additional","affiliation":[{"name":"Windward Islands Research and Education Foundation True Blue Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-8414","authenticated-orcid":false,"given":"V","family":"Mapp\u2010Alexander","sequence":"additional","affiliation":[{"name":"Windward Islands Research and Education Foundation True Blue Grenada"},{"name":"St. George's University St. Georges Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Ministry of Health St. Georges Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-7856","authenticated-orcid":false,"given":"C","family":"Macpherson","sequence":"additional","affiliation":[{"name":"Windward Islands Research and Education Foundation True Blue Grenada"},{"name":"St. George's University St. Georges Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-4245","authenticated-orcid":false,"given":"R","family":"Waechter","sequence":"additional","affiliation":[{"name":"Windward Islands Research and Education Foundation True Blue Grenada"},{"name":"St. George's University St. Georges Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-6867","authenticated-orcid":false,"given":"AD","family":"LaBeaud","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Department of Pediatrics Stanford University, School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406035"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(55)90080-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40403"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx234"},{"key":"e_1_2_7_6_1","unstructured":"World Health Organization.Number of reported cases of chikungunya fever in the Americas by country or territory 2013\u20132014 Cumulative cases Epidemiological Week\/EW 52. 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