{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:54:49Z","timestamp":1788260089584,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine early and late pregnancy loss in women with and without polycystic ovary syndrome (PCOS) undergoing IVF\/ICSI transfers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Reproductive medicine centre at a tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>We studied women with a positive \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) after in vitro fertilisation\/intra\u2010cytoplasmic sperm injection (IVF\/ICSI) treatment from May 2014 to April 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Odds ratios (OR) for early (\u226413\u00a0weeks) and late (&gt;13\u00a0weeks) pregnancy loss were calculated among women with and without PCOS for plurality of the pregnancy with adjustment for confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Early pregnancy loss (EPL) and late pregnancy loss (LPL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 21\u00a0820 women identified with a positive \u03b2\u2010hCG, 2357 (10.8%) women had PCOS, and 19\u00a0463 (89.2%) women did not. EPL occurred in 16.6% (391) of women with PCOS versus 18.3% (3565) in women with non\u2010PCOS (OR 0.89, 95% CI 0.79\u20130.99, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.04). After adjustment for age and other confounders, the rate of EPL was not statistically significantly associated with PCOS status (adjusted OR [aOR] 0.91, 95% CI 0.80\u20131.05). Women with PCOS demonstrated a higher rate of LPL (6.4% in PCOS versus 3.6% in non\u2010PCOS, OR 1.81, 95% CI 1.48\u20132.21, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In multivariable analysis, the potential impact of PCOS was less strong (aOR 1.38, 95% CI 0.96\u20131.98), with BMI and maternal comorbidities also associated with LPL (aOR 1.08, 95% CI 1.04\u20131.1 and aOR 2.07, 95% CI 1.43\u20133.00, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polycystic ovary syndrome was not independently associated with EPL. There was an increased risk of LPL but this difference was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Polycystic ovary syndrome women are at increased risk of late pregnancy loss, partly driven by elevated BMI and maternal comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.16590","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T18:57:17Z","timestamp":1604429837000},"page":"1160-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Early and late pregnancy loss in women with polycystic ovary syndrome undergoing IVF\/ICSI treatment: a retrospective cohort analysis of 21\u00a0820 pregnancies"],"prefix":"10.1111","volume":"128","author":[{"given":"He","family":"Cai","sequence":"first","affiliation":[{"name":"Assisted Reproduction Centre Northwest Women and Children\u2019s Hospital Xi\u2019an 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